Evidence map›Paper›PMID 26319943›Full record

ReviewMethods (San Diego, Calif.)2016

The hematopoietic system in the context of regenerative medicine.

Christopher D Porada, Anthony J Atala, Graça Almeida-Porada

Abstract readReview
In one paragraph

Review in Methods (San Diego, Calif.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Importance and regulation of adult stem cell migration.Journal of cellular and molecular medicine · 2018
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Tissue Engineering and Regenerative Medicine - New Initiatives for Individual Treatment Offers.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2016
    Article
  18. Review
  19. Hematopoietic Stem Cells in Regenerative Medicine: Astray or on the Path?Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2016
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christopher D PoradaWake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, 391 Technology Way, Winston-Salem, NC 27157-1083, United States. Electronic address: cporada@wakehealth.edu.
Anthony J AtalaWake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, 391 Technology Way, Winston-Salem, NC 27157-1083, United States. Electronic address: aatala@wakehealth.edu.
Graça Almeida-PoradaWake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, 391 Technology Way, Winston-Salem, NC 27157-1083, United States. Electronic address: galmeida@wakehealth.edu.

Funding

Functional Analysis of the Hematopoietic Niche during OntogenyR01HL097623 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ALMEIDA-PORADA, GRACA DUARTE · 2009 to 2012
$1.4M
Cord Blood Expansion Inside a Bioengineered LiverR21HL117704 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ALMEIDA-PORADA, GRACA DUARTE, SOKER, SHAY · 2013 to 2014
$228k
NHLBI NIH HHS R01 HL097623NHLBI NIH HHS R01-HL097623NHLBI NIH HHS R21 HL117704NHLBI NIH HHS R21-HL117704
6 · The paper itself

Abstract

Hematopoietic stem cells (HSC) represent the prototype stem cell within the body. Since their discovery, HSC have been the focus of intensive research, and have proven invaluable clinically to restore hematopoiesis following inadvertent radiation exposure and following radio/chemotherapy to eliminate hematologic tumors. While they were originally discovered in the bone marrow, HSC can also be isolated from umbilical cord blood and can be "mobilized" peripheral blood, making them readily available in relatively large quantities. While their ability to repopulate the entire hematopoietic system would already guarantee HSC a valuable place in regenerative medicine, the finding that hematopoietic chimerism can induce immunological tolerance to solid organs and correct autoimmune diseases has dramatically broadened their clinical utility. The demonstration that these cells, through a variety of mechanisms, can also promote repair/regeneration of non-hematopoietic tissues as diverse as liver, heart, and brain has further increased their clinical value. The goal of this review is to provide the reader with a brief glimpse into the remarkable potential HSC possess, and to highlight their tremendous value as therapeutics in regenerative medicine.

Indexed as

Hematopoietic Stem Cell TransplantationRegenerative MedicineAnimalsAutoimmune DiseasesHematologic DiseasesHematopoiesisHematopoietic Stem CellsHumansImmune ToleranceAlternate sources of HSCBone marrowHematopoietic stem cell (HSC)HSC for repairing non-hematopoietic tissuesHSC for tolerance inductionTransplantation

Identifiers

PMID26319943
PMCPMC4769971

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.