ArticleApplied and environmental microbiology2015
Metabolism of Fructooligosaccharides in Lactobacillus plantarum ST-III via Differential Gene Transcription and Alteration of Cell Membrane Fluidity.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 60 citations in OpenAlex.
- Exploratory comparison of extracellular proteomic, metabolomic, and lipidomic profiling of inulin-fortified gelatin capsule waste gel fermented byFood chemistry. Molecular sciences · 2026Article
- Fructooligosaccharides-driven metabolism of a definedFrontiers in microbiology · 2026Article
- The effect of complex prebiotics on quality and functional properties of synbiotic fermented milk.Food chemistry: X · 2025Article
- Recent developments in the production of prebiotic fructooligosaccharides using fungal fructosyltransferases.Mycology · 2024Review
- Article
- Transcriptional control of carbohydrate catabolism by the CcpA protein in the ruminal bacteriumApplied and environmental microbiology · 2023Article
- Persistence of maternal milk derivedFood science and biotechnology · 2023Article
- Effects ofFood science and biotechnology · 2023Article
- Unraveling the mechanism of raffinose utilization in3 Biotech · 2022Article
- Metagenomic Analysis of the Effects ofFoods (Basel, Switzerland) · 2022Article
- Sweet Immunity Aspects during Levan Oligosaccharide-Mediated Priming in Rocket againstBiomolecules · 2022Article
- The Carbohydrate Metabolism ofInternational journal of molecular sciences · 2021Article
- Identification of genes encoding a novel ABC transporter in Lactobacillus delbrueckii for inulin polymers uptake.Scientific reports · 2021Article
- Effects of CcpA against salt stress in Lactiplantibacillus plantarum as assessed by comparative transcriptional analysis.Applied microbiology and biotechnology · 2021Article
- Global transcriptomic analysis of functional oligosaccharide metabolism in Pediococcus pentosaceus.Applied microbiology and biotechnology · 2021Article
- Role of Lactic Acid Bacteria Phospho-β-Glucosidases during the Fermentation of Cereal by-Products.Foods (Basel, Switzerland) · 2021Article
- Transcriptome Analysis Reveals Catabolite Control Protein A Regulatory Mechanisms Underlying Glucose-Excess or -Limited Conditions in a Ruminal Bacterium,Frontiers in microbiology · 2021Article
- Comparative Genomic and Functional Evaluations ofFoods (Basel, Switzerland) · 2020Article
- The local transcriptional regulators SacR1 and SacR2 act as repressors of fructooligosaccharides metabolism in Lactobacillus plantarum.Microbial cell factories · 2020Article
- Dietary Components, Microbial Metabolites and Human Health: Reading between the Lines.Foods (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although fructooligosaccharides (FOS) can selectively stimulate the growth and activity of probiotics and beneficially modulate the balance of intestinal microbiota, knowledge of the molecular mechanism for FOS metabolism by probiotics is still limited. Here a combined transcriptomic and physiological approach was used to survey the global alterations that occurred during the logarithmic growth of Lactobacillus plantarum ST-III using FOS or glucose as the sole carbon source. A total of 363 genes were differentially transcribed; in particular, two gene clusters were induced by FOS. Gene inactivation revealed that both of the clusters participated in the metabolism of FOS, which were transported across the membrane by two phosphotransferase systems (PTSs) and were subsequently hydrolyzed by a β-fructofuranosidase (SacA) in the cytoplasm. Combining the measurements of the transcriptome- and membrane-related features, we discovered that the genes involved in the biosynthesis of fatty acids (FAs) were repressed in cells grown on FOS; as a result, the FA profiles were altered by shortening of the carbon chains, after which membrane fluidity increased in response to FOS transport and utilization. Furthermore, incremental production of acetate was observed in both the transcriptomic and the metabolic experiments. Our results provided new insights into gene transcription, the production of metabolites, and membrane alterations that could explain FOS metabolism in L. plantarum.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.