ArticlePsychiatry research2015
Affective personality predictors of disrupted reward learning and pursuit in major depressive disorder.
Article in Psychiatry research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Sensitivity to intrinsic rewards is domain general and related to mental health.Nature. Mental health · 2023Article
- Relations of gray matter volume to dimensional measures of cognition and affect in mood disorders.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
- Using Network Parcels and Resting-State Networks to Estimate Correlates of Mood Disorder and Related Research Domain Criteria Constructs of Reward Responsiveness and Inhibitory Control.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Neurocognitive predictors of self-reported reward responsivity and approach motivation in depression: A data-driven approach.Depression and anxiety · 2020Article
- Influence of childhood adversity, approach motivation traits, and depression on individual differences in brain activation during reward anticipation.Biological psychology · 2019Article
- Article
- The Titrated Monetary Incentive Delay Task: Sensitivity, convergent and divergent validity, and neural correlates in an RDoC sample.Journal of clinical and experimental neuropsychology · 2019Article
- Multidimensional imaging techniques for prediction of treatment response in major depressive disorder.Progress in neuro-psychopharmacology & biological psychiatry · 2019Article
- Cluster analysis with MOODS-SR illustrates a potential bipolar disorder risk phenotype in young adults with remitted major depressive disorder.Bipolar disorders · 2018Article
- Neural Correlates of Impaired Reward-Effort Integration in Remitted Bulimia Nervosa.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Affective traits and history of depression are related to ventral striatum connectivity.Journal of affective disorders · 2017Article
- Learning and Choice in Mood Disorders: Searching for the Computational Parameters of Anhedonia.Computational psychiatry (Cambridge, Mass.) · 2017Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Anhedonia, the diminished anticipation and pursuit of reward, is a core symptom of major depressive disorder (MDD). Trait behavioral activation (BA), as a proxy for anhedonia, and behavioral inhibition (BI) may moderate the relationship between MDD and reward-seeking. The present studies probed for reward learning deficits, potentially due to aberrant BA and/or BI, in active or remitted MDD individuals compared to healthy controls (HC). Active MDD (Study 1) and remitted MDD (Study 2) participants completed the modified monetary incentive delay task (mMIDT), a behavioral reward-seeking task whose response window parameters were individually titrated to theoretically elicit equivalent accuracy between groups. Participants completed the BI Scale and BA Reward-Responsiveness and Drive Scales. Despite individual titration, active MDD participants won significantly less money than HCs. Higher Reward-Responsiveness scores predicted more won; Drive and BI were not predictive. Remitted MDD participants' performance did not differ from controls', and trait BA and BI measures did not predict r-MDD performance. These results suggest that diminished reward-responsiveness may contribute to decreased motivation and reward pursuit during active MDD, but that reward learning is intact in remission. Understanding individual reward processing deficits in MDD may inform personalized intervention addressing anhedonia and motivation deficits in select MDD patients.
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