Evidence map›Paper›PMID 26319542›Full record

ArticleJournal of biomedical informatics2015

Coronary artery disease risk assessment from unstructured electronic health records using text mining.

Jitendra Jonnagaddala, Siaw-Teng Liaw, Pradeep Ray, Manish Kumar, Nai-Wen Chang, Hong-Jie Dai

Abstract read
In one paragraph

Article in Journal of biomedical informatics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  14. Different Data Mining Approaches Based Medical Text Data.Journal of healthcare engineering · 2021
    Review
  15. Clinical concept extraction: A methodology review.Journal of biomedical informatics · 2020
    Review
  16. Big data analytics for preventive medicine.Neural computing & applications · 2020
    Article
  17. Review
  18. Merging Data Diversity of Clinical Medical Records to Improve Effectiveness.International journal of environmental research and public health · 2019
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jitendra JonnagaddalaSchool of Public Health and Community Medicine, University of New South Wales, Australia; Asia-Pacific Ubiquitous Healthcare Research Centre, University of New South Wales, Australia; Prince of Wales Clinical School, University of New South Wales, Australia.
Siaw-Teng LiawSchool of Public Health and Community Medicine, University of New South Wales, Australia. Electronic address: siaw@unsw.edu.au.
Pradeep RayAsia-Pacific Ubiquitous Healthcare Research Centre, University of New South Wales, Australia.
Manish KumarPrince of Wales Clinical School, University of New South Wales, Australia.
Nai-Wen ChangInstitution of Information Science, Academia Sinica, Taiwan; Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taiwan.
Hong-Jie DaiDepartment of Computer Science and Information Engineering, National Taitung University, Taiwan. Electronic address: hjdai@nttu.edu.tw.

Funding

Informatics for Integrating Biology/ the Bedside (RMI)U54LM008748 · NLM · BRIGHAM AND WOMEN'S HOSPITAL · PI KOHANE, ISAAC S. · 2004 to 2013
$39.0M
Challenges in Natural Language Processing in Clinical TextR13LM011411 · NLM · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI UZUNER, OZLEM · 2012 to 2016
$98k
NLM NIH HHS R13 LM011411NLM NIH HHS U54 LM008748
6 · The paper itself

Abstract

Coronary artery disease (CAD) often leads to myocardial infarction, which may be fatal. Risk factors can be used to predict CAD, which may subsequently lead to prevention or early intervention. Patient data such as co-morbidities, medication history, social history and family history are required to determine the risk factors for a disease. However, risk factor data are usually embedded in unstructured clinical narratives if the data is not collected specifically for risk assessment purposes. Clinical text mining can be used to extract data related to risk factors from unstructured clinical notes. This study presents methods to extract Framingham risk factors from unstructured electronic health records using clinical text mining and to calculate 10-year coronary artery disease risk scores in a cohort of diabetic patients. We developed a rule-based system to extract risk factors: age, gender, total cholesterol, HDL-C, blood pressure, diabetes history and smoking history. The results showed that the output from the text mining system was reliable, but there was a significant amount of missing data to calculate the Framingham risk score. A systematic approach for understanding missing data was followed by implementation of imputation strategies. An analysis of the 10-year Framingham risk scores for coronary artery disease in this cohort has shown that the majority of the diabetic patients are at moderate risk of CAD.

Indexed as

NarrationNatural Language ProcessingAgedCardiovascular DiseasesCohort StudiesComorbidityComputer SecurityConfidentialityData MiningDiabetes ComplicationsElectronic Health RecordsFemaleHumansIncidenceLongitudinal StudiesMaleCoronary artery diseaseEHRFramingham risk scoreTemporal dataText mining

Identifiers

PMID26319542
PMCPMC4985289

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.