ArticleJACC. Cardiovascular imaging2015
LV Mass as a Predictor of CVD Events in Older Adults With and Without Metabolic Syndrome and Diabetes.
Article in JACC. Cardiovascular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
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- Mechanical dispersion predicts survival of dialysis-dependent patients with preserved left ventricular ejection fraction.Internal and emergency medicine · 2025Article
- OPPORTUNISTIC ASSESSMENT OF CARDIOVASCULAR RISK USING AI-DERIVED STRUCTURAL AORTIC AND CARDIAC PHENOTYPES FROM NON-CONTRAST CHEST COMPUTED TOMOGRAPHY.medRxiv : the preprint server for health sciences · 2025Article
- In Utero Exposure to Maternal SARS-CoV-2 Infection Is Associated With Higher Left Ventricular Mass in Toddlers.Open forum infectious diseases · 2024Article
- Insulin resistance/hyperinsulinemia: an important cardiovascular risk factor that has long been underestimated.Frontiers in cardiovascular medicine · 2024Article
- Sex, gender, and subclinical hypertensiveorgan damage-heart.Journal of human hypertension · 2023Review
- Association between the number of pregnancies and cardiac target organ damages: a cross-sectional analysis of data from the Korean women's chest pain registry (KoROSE).BMC women's health · 2023Article
- Extracellular volume and left ventricular hypertrophy by cardiac magnetic resonance are independent predictors of cardiovascular outcome in obesity.Scientific reports · 2022Article
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- Liver stiffness measurement identifies subclinical myocardial dysfunction in non-advanced non-alcoholic fatty liver disease patients without overt heart disease.Internal and emergency medicine · 2022Article
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- Prognostic Value of CTA-Derived Left Ventricular Mass in Neonates with Congenital Heart Disease.Diagnostics (Basel, Switzerland) · 2021Article
- It's Time to Add Electrocardiography and Echocardiography to CVD Risk Prediction Models: Results from a Prospective Cohort Study.Risk management and healthcare policy · 2021Article
- A Cross-Sectional Examination of 10-Year Atherosclerotic Cardiovascular Disease Risk Among US Firefighters by Age and Weight Status.Journal of occupational and environmental medicine · 2020Article
- Cardiac left ventricular myocardial tissue density, evaluated by computed tomography and autopsy.BMC medical imaging · 2019Article
- Subclinical alterations in left ventricular structure and function according to obesity and metabolic health status.PloS one · 2019Article
- Association of glycemic status and segmental left ventricular wall thickness in subjects without prior cardiovascular disease: a cross-sectional study.BMC cardiovascular disorders · 2018Article
- Impact of lung-function measures on cardiovascular disease events in older adults with metabolic syndrome and diabetes.Clinical cardiology · 2018Article
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7 authors at 6 institutions in 1 country.
Funding
Abstract
objectivesThe purpose of this study was to examine the prognostic significance of left ventricular (LV) mass for cardiovascular disease (CVD) events in older adults with and without metabolic syndrome (MetS) and diabetes mellitus (DM).
backgroundMetS and DM are associated with increased CVD risk, but it is unclear in these groups whether subclinical CVD as shown by increased LV mass improves risk prediction compared to standard risk factors in older individuals.
methodsWe studied 3,724 adults (mean 72.4 ± 5.4 years of age, 61.0% female, 4.4% African-American) from the Cardiovascular Health Study who had MetS but not DM or had DM alone or had neither condition. Cox regression was used to examine the association of LV mass, (alone and indexed by height and body surface area [BSA]) as determined by echocardiography, with CVD events, including coronary heart disease (CHD), stroke, heart failure (HF), and CVD death, as well as total mortality. We also assessed the added prediction, discriminative value, and net reclassification improvement (NRI) for clinical utility of LV mass compared to standard risk factors.
resultsOver a mean follow-up of 14.2 ± 6.3 years, 2,180 subjects experienced CVD events, including 986 CVD deaths. After adjustment for age, sex and standard risk factors, LV mass was positively associated with CVD events in those with MetS (hazard ratio [HR]: 1.4, p < 0.001) and without MetS (HR: 1.4, p < 0.001), but not DM (HR: 1.0, p = 0.62), with similar findings for LV mass indexed for height or BSA. Adding LV mass to standard risk factors moderately improved the prediction accuracy in the overall sample and MetS group from changes in C-statistics (p < 0.05). Categorical-free net reclassification improvement increased significantly by 17% to 19% in those with MetS. Findings were comparable for CHD, CVD mortality, and total mortality.
conclusionsLV mass is associated with increased CVD risk and provides modest added prediction and clinical utility compared to standard risk factors in older persons with and without MetS but not with DM.
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