ArticleWorld journal of surgery2016
How Do Quality-of-Life and Gastrointestinal Symptoms Differ Between Post-cholecystectomy Patients and the Background Population?
Article in World journal of surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Patient-reported outcome measures (PROMs) after laparoscopic cholecystectomy: systematic review.BJS open · 2022Pooled it
- Postcholecystectomy diarrhoea rate and predictive factors: a systematic review of the literature.BMJ open · 2022Pooled it
- Patient-reported Outcome Measure (PROM) Rand-36-item Health Survey for Gallstone Disease Patients Five Years Following Surgery: A Prospective Randomized Study.In vivo (Athens, Greece)Trial
- Gallbladder-preserving cholelithotomy in selected patients with symptomatic cholelithiasis: A case series.International journal of surgery case reports · 2025Review
- Asymptomatic gallstone disease: Re-evaluating the threshold for surgical options in the era of precision medicine.World journal of gastrointestinal surgery · 2025Review
- Analysis of the incidence of post-cholecystectomy diarrhea and its influencing factors in Hainan Province.BMC gastroenterology · 2025Article
- Cholecystectomy for asymptomatic gallstones: Markov decision tree analysis.World journal of clinical cases · 2022Review
- The Need for Standardizing Diagnosis, Treatment and Clinical Care of Cholecystitis and Biliary Colic in Gallbladder Disease.Medicina (Kaunas, Lithuania) · 2022Review
- Rates of Bile Acid Diarrhoea After Cholecystectomy: A Multicentre Audit.World journal of surgery · 2021Article
- A systematic review of patient reported outcome measures (PROMs) and quality of life reporting in patients undergoing laparoscopic cholecystectomy.Hepatobiliary surgery and nutrition · 2019Review
- Patient reported outcomes in elective laparoscopic cholecystectomy.Annals of hepato-biliary-pancreatic surgery · 2019Article
- Postcholecystectomy syndrome: symptom clusters after laparoscopic cholecystectomy.Annals of surgical treatment and research · 2018Article
- Index admission laparoscopic cholecystectomy for acute cholecystitis restores Gastrointestinal Quality of Life Index (GIQLI) score.Annals of hepato-biliary-pancreatic surgery · 2018Article
- Quality of life and psychological and gastrointestinal symptoms after cholecystectomy: a population-based cohort study.BMJ open gastroenterology · 2017Article
- Predictors of Diarrhea after Hepatectomy and Its Impact on Gastrointestinal Quality of Life in Living Donors.PloS one · 2016Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have indicated a correlation between indication for cholecystectomy and long-term gastrointestinal quality-of-life (QoL). The aim of the present study was to compare QoL in a post-cholecystectomy cohort with the background population and with historical controls.
methodsA post-cholecystectomy study group (on average 4 years after cholecystectomy) was compared with a control group from the background population using the Gastrointestinal Quality-of-Life Index (GIQLI). EQ-5D scores were compared with expected scores derived from recent historical data.
resultsThe post-cholecystectomy study group (N = 451) had better QoL measured by the EQ-5D compared with historical controls (p < 0.001), similar total GIQLI scores as the control group (N = 390), but scored worse on the GIQLI gastrointestinal symptoms subscale score (p < 0.001). The results include an item-by-item breakdown of the GIQLI questionnaire where the scores for diarrhea, bowel urgency, bloating, regurgitation, abdominal pain, flatus, fullness, nausea, uncontrolled stools, belching, heartburn, restricted eating, and bowel frequency were found to be significantly lower (i.e. worse) in the post-cholecystectomy cohort than in the control group. The opposite was true for relationships, endurance, sexual life, physical strength, feeling fit, not being frustrated by illness, and being able to carry out leisure activities, i.e. items related to general performance and well-being.
conclusionsIn this study, QoL after cholecystectomy was good, but there was an increased prevalence of gastrointestinal symptoms compared to the background population.
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Registered trials
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