ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2015
Aspergillus fumigatus chronic colonization and lung function decline in cystic fibrosis may have a two-way relationship.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Review
- Drivers of diversification in fungal pathogen populations.PLoS pathogens · 2024Review
- Long-Term Outcomes of Allergic Bronchopulmonary Aspergillosis andJournal of fungi (Basel, Switzerland) · 2024Article
- Insights intoJournal of fungi (Basel, Switzerland) · 2024Article
- The Clinical Association betweenAnnals of the American Thoracic Society · 2023Article
- Clinical Impact ofMicroorganisms · 2022Article
- Review
- The Effects ofJournal of fungi (Basel, Switzerland) · 2021Article
- Emerging Fungal Threats in Cystic Fibrosis.Mycopathologia · 2021Review
- Article
- New Insights in Microbial Species Predicting Lung Function Decline in CF: Lessons from the MucoFong Project.Journal of clinical medicine · 2021Article
- Allergic Diseases Caused byAntibiotics (Basel, Switzerland) · 2021Review
- The fungal airway microbiome in cystic fibrosis and non-cystic fibrosis bronchiectasis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2021Article
- Managing Fungal Infections in Cystic Fibrosis Patients: Challenges in Clinical Practice.Infection and drug resistance · 2021Review
- Allergic Bronchopulmonary Aspergillosis in Children with Cystic Fibrosis: An Update on the Newest Diagnostic Tools and Therapeutic Approaches.Pathogens (Basel, Switzerland) · 2020Review
- Early Aspergillosis in Cystic Fibrosis and Air Trapping: Guilt by Association?American journal of respiratory and critical care medicine · 2020Article
- Comparative Analysis of Clinical Parameters and Sputum Biomarkers in Establishing the Relevance of Filamentous Fungi in Cystic Fibrosis.Frontiers in cellular and infection microbiology · 2020Article
- The presence of Aspergillus fumigatus is associated with worse respiratory quality of life in cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2020Article
- Risk factors for persistent Aspergillus respiratory isolation in cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2018Article
- Aspergillus Bronchitis in Patients with Cystic Fibrosis.Mycopathologia · 2018Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aspergillus fumigatus is commonly found in cystic fibrosis (CF) airways. Our aim was to assess the relationship between A. fumigatus chronic colonization and lung function in CF patients. A case-control study of CF patients born from 1989 to 2002 was performed. Medical records were reviewed from the time of initial diagnosis until December 2013. Chronic colonization was defined as two or more positive sputum cultures in a given year. Each patient chronically colonized with A. fumigatus was matched with three control patients (never colonized by A. fumigatus) for age, sex, and year of birth (±3 years). A number of parameters were recorded and analyzed prospectively. The primary outcome measure was the difference in forced expiratory volume in 1 s (FEV1) in percent predicted between groups. Linear mixed models were used for longitudinal analyses to evaluate the relationship between A. fumigatus chronic colonization and lung function during a 7-year period and study the lung function 4 years before the time of enrollment (t0). Twenty patients had chronic colonization and were matched with 60 controls. A significant difference in lung function was detected throughout the 7-year period after adjustment for confounders (est = 8.66, p = 0.020). Four years before t0, FEV1 baseline was the only factor associated with the course of lung function (est = 0.64, p < 0.001) and was significantly different between groups (p = 0.001). In conclusion, a decreased FEV1 baseline appears to be a risk factor for chronic colonization by A. fumigatus, which, in turn, may cause a faster deterioration of lung function.
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