Evidence map›Paper›PMID 26319134›Full record

Trial reportBMC research notes2015

Vitamin D supplementation to patients with frequent respiratory tract infections: a post hoc analysis of a randomized and placebo-controlled trial.

Peter Bergman, Anna-Carin Norlin, Susanne Hansen, Linda Björkhem-Bergman

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC research notes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01131858 (A Placebo Controlled Double Blinded Study of Vitamin D3 Substitution to Patients With Primary Immunodeficiency), which is not on this map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01131858 phase1 / phase2completednot on this map

A Placebo Controlled Double Blinded Study of Vitamin D3 Substitution to Patients With Primary Immunodeficiency

TypeinterventionalSponsorKarolinska University HospitalRan2010 to 2011Enrolled140ConditionsPrimary Immune Deficiency DisorderArmsVigantol, Placebo
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Review
  7. Article
  8. Are Vitamin DNutrients · 2020
    Observational
  9. Antibiotic resistance: a rundown of a global crisis.Infection and drug resistance · 2018
    Review
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Peter BergmanDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet and Karolinska University Hospital Huddinge, 141 86, Stockholm, Sweden. peter.bergman@ki.se.
Anna-Carin NorlinDivision of Clincal Immunology, Karolinska Institutet and Karolinska University Hospital Huddinge, 141 86, Stockholm, Sweden. anna-carin.norlin@karolinska.se.
Susanne HansenInfectious Disease Clinic, Karolinska University Hospital, 141 86, Stockholm, Sweden. susanne.hansen@karolinska.se.
Linda Björkhem-BergmanDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet and Karolinska University Hospital Huddinge, 141 86, Stockholm, Sweden. linda.bjorkhem-bergman@ki.se.
Karolinska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D is considered to be important for a healthy immune system. The aim of this study was to test the hypothesis that vitamin D supplementation reduces number of respiratory tract infections (RTIs) and prolong the time to the first RTI in adult patients with frequent RTIs.

methodsWe performed a post hoc analysis of a randomized, placebo-controlled and double-blinded study, where adult patients with a high burden of RTIs were randomized to placebo or vitamin D (4000 IE/day for 1 year, n = 124 in the per protocol cohort presented here).

resultsVitamin D supplementation increased the probability to stay free of RTI during the study year (RR 0.64, 95% CI 0.43-0.94). Further, the total number of RTIs was also reduced in the vitamin D-group (86 RTIs) versus placebo (120 RTIs; p = 0.05). Finally, the time to the first RTI was significantly extended in the vitamin D-group (HR 1.68, 95% CI 1.03-2.68, p = 0.0376).

conclusionVitamin D supplementation was found to significantly increase the probability of staying infection free during the study period. This finding further supports the notion that vitamin D-status should be monitored in adult patients with frequent RTIs and suggests that selected patients with vitamin D deficiency are supplemented. This could be a safe and cheap way to reduce RTIs and improve health in this vulnerable patient population. The original trial was registered at http://www.clinicaltrials.gov (NCT01131858).

Indexed as

Dietary SupplementsAdultCohort StudiesHumansPlacebosRespiratory Tract InfectionsVitamin DPlacebosVitamin D

Identifiers

PMID26319134
PMCPMC4553208
OpenAlexW2122291394

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.