Evidence map›Paper›PMID 26319059›Full record

ReviewVaccine2015

Moving targets: The challenges of studying infectious diseases among pregnant women in resource limited settings.

Titus H Divala, Randy G Mungwira, Miriam K Laufer

Abstract readReview
In one paragraph

Review in Vaccine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. The remarkable tenacity of sulfadoxine-pyrimethamine.The Lancet. Infectious diseases · 2019
    Article
  6. Article
  7. Group BF1000Research · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Titus H DivalaBlantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi.
Randy G MungwiraBlantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi.
Miriam K LauferInstitute for Global Health, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: mlaufer@medicine.umaryland.edu.

Funding

Clinical trial of trimethoprim-sulfamethoxazole or chloroquine in adults on ARTU01AI089342 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LAUFER, MIRIAM K. · 2011 to 2017
$13.7M
Clinical trial of chloroquine weekly or as IPT to prevent malaria in pregnancy inU01AI087624 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LAUFER, MIRIAM K. · 2010 to 2013
$5.3M
NIAID NIH HHS U01 AI087624NIAID NIH HHS U01AI087624NIAID NIH HHS U01 AI089342NIAID NIH HHS U01AI089342
6 · The paper itself

Abstract

Conducting clinical trials to prevent and treat infectious diseases in pregnancy is essential to saving maternal and newborn lives, though it is fraught with challenges. We have been conducting research in malaria treatment and prevention in children and pregnant women in Blantyre, Malawi for over a decade. Here, we review some of the unique challenges that we have faced in leading research studies that with rigor and integrity and maintaining the highest ethical standard. We conclude with concrete strategies to overcome some of the apparent obstacles that frequently focus on building trust through bidirectional communication with local health workers and communities. We also highlight the key role of local and international investigators to advocate for the health of the communities in which they work.

Indexed as

Health CommunicationClinical Studies as TopicDeveloping CountriesFemaleHumansMalariaMalawiPregnancyPregnancy Complications, InfectiousAntenatal careClinical trialsGeneralizabilityInfectious diseasesInternational healthPregnancy

Identifiers

PMID26319059
PMCPMC4920047

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.