Evidence map›Paper›PMID 26319043›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2016

Relationship between matrix metalloproteinase-9 and common carotid artery intima media thickness.

Maged Abdelnaseer, Nervana Elfayomi, Eman H Esmail, Manal M Kamal, Ahmed Hamdy, Rasha M Abdel Samie, Enji Elsawy

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03194204 (Efficacy of Doxycycline as a Combination Therapy in the Treatment of Rheumatoid Arthritis), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03194204 nacompletednot on this mapstarted 2019, after this paper: background citation

Efficacy of Doxycycline as a Combination Therapy in the Treatment of Rheumatoid Arthritis

TypeinterventionalSponsorAssiut UniversityRan2019 to 2020Enrolled160ConditionsRheumatoid ArthritisArmsDoxycycline Tablets
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Maged AbdelnaseerNeurology Department, Cairo University, 49 Misr Hilwan Elzraai Street, Maadi, Cairo, 2218, Egypt.
Nervana ElfayomiNeurology Department, Cairo University, 49 Misr Hilwan Elzraai Street, Maadi, Cairo, 2218, Egypt.
Eman H EsmailNeurology Department, Cairo University, 49 Misr Hilwan Elzraai Street, Maadi, Cairo, 2218, Egypt. emaan_neuro@yahoo.com.ORCID http://orcid.org/0000-0002-7486-7593
Manal M KamalChemical and Clinical Pathology Department, Cairo University, Cairo, Egypt.
Ahmed HamdyInternal Medicine Department, Cairo University, Cairo, Egypt.
Rasha M Abdel SamieInternal Medicine Department, Cairo University, Cairo, Egypt.
Enji ElsawyNeurology Department, Cairo University, 49 Misr Hilwan Elzraai Street, Maadi, Cairo, 2218, Egypt.
Cairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis causes significant morbidity and mortality. Carotid intima media thickness (IMT) predicts future ischaemic strok e incidence. Matrix metalloproteinases (MMPs) play a considerable role in atherosclerosis and hold therapeutic promise as well. To investigate the relationship between serum level of matrix metalloproteinase-9 (MMP-9) and common carotid artery intima media thickness (CCA-IMT) in patients with ischaemic stroke and asymptomatic subjects. Thirty patients with a previous ischaemic stroke and 30 asymptomatic volunteers were recruited. Assessment of vascular risk factors, serum level of MMP-9 and CCA-IMT on both sides was performed. The IMT of both CCAs correlated positively with the serum MMP-9 level in asymptomatic subjects (p = 0.000), even after adjustment for other risk factors. In the patients group, this positive correlation was significant for the right but not for the left CCA (right CCA: p = 0.023, left CCA: p = 0.0284). Fasting blood sugar correlated positively with serum levels of MMP-9 in asymptomatic subjects (p = 0.005) but did not correlate positively in patients. There was no significant correlation between MMP-9 and age or other investigated laboratory risk factors in either the patient or asymptomatic groups. MMP-9 is positively correlated with CCA-IMT both in stroke patients and asymptomatic subjects. This may indicate that MMP-9 is a possible therapeutic target for stroke prevention.

Indexed as

Carotid Intima-Media ThicknessAgedBiomarkersBlood GlucoseBrain IschemiaCarotid Artery, CommonCase-Control StudiesFemaleFunctional LateralityHumansMaleMatrix Metalloproteinase 9Middle AgedRisk FactorsStrokeBiomarkersBlood GlucoseMatrix Metalloproteinase 9MMP9 protein, humanAtherosclerosisCarotidMedia thicknessMetalloproteinaseMMP-9

Identifiers

PMID26319043
OpenAlexW1912555701

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.