ArticleNucleic acids research2015
Sumoylation of Sir2 differentially regulates transcriptional silencing in yeast.
Article in Nucleic acids research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- The role of SUMOylation in biomolecular condensate dynamics and protein localization.Cell insight · 2024Review
- Insights into the modulation of bacterial NADase activity by phage proteins.Nature communications · 2024Article
- Systematic characterization ofFrontiers in microbiology · 2023Article
- SUMO is a pervasive regulator of meiosis.eLife · 2021Article
- Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence.PLoS genetics · 2020Article
- Cell organelles and yeast longevity: an intertwined regulation.Current genetics · 2020Review
- Recruitment of an Activated Gene to the Yeast Nuclear Pore Complex Requires Sumoylation.Frontiers in genetics · 2020Article
- Elevated dosage of Ulp1 disrupts telomeric silencing in Saccharomyces cerevisiae.Molecular biology reports · 2018Article
- Epigenetics in ovarian cancer: premise, properties, and perspectives.Molecular cancer · 2018Review
- Rice NAD+-dependent histone deacetylase OsSRT1 represses glycolysis and regulates the moonlighting function of GAPDH as a transcriptional activator of glycolytic genes.Nucleic acids research · 2017Article
- Yeast silencing factor Sir4 and a subset of nucleoporins form a complex distinct from nuclear pore complexes.The Journal of cell biology · 2017Article
- Epigenetic dysfunctional diseases and therapy for infection and inflammation.Biochimica et biophysica acta. Molecular basis of disease · 2017Review
- Review
- Identification of Components of the SUMOylation Machinery in Candida glabrata: ROLE OF THE DESUMOYLATION PEPTIDASE CgUlp2 IN VIRULENCE.The Journal of biological chemistry · 2016Article
- The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae.Genetics · 2016Review
- Article
- Intron or no intron: a matter for nuclear pore complexes.Nucleus (Austin, Tex.) · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Silent information regulator 2 (Sir2), the founding member of the conserved sirtuin family of NAD(+)-dependent histone deacetylase, regulates several physiological processes including genome stability, gene silencing, metabolism and life span in yeast. Within the nucleus, Sir2 is associated with telomere clusters in the nuclear periphery and rDNA in the nucleolus and regulates gene silencing at these genomic sites. How distribution of Sir2 between telomere and rDNA is regulated is not known. Here we show that Sir2 is sumoylated and this modification modulates the intra-nuclear distribution of Sir2. We identify Siz2 as the key SUMO ligase and show that multiple lysines in Sir2 are subject to this sumoylation activity. Mutating K215 alone counteracts the inhibitory effect of Siz2 on telomeric silencing. SUMO modification of Sir2 impairs interaction with Sir4 but not Net1 and, furthermore, SUMO modified Sir2 shows predominant nucleolar localization. Our findings demonstrate that sumoylation of Sir2 modulates distribution between telomeres and rDNA and this is likely to have implications for Sir2 function in other loci as well.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.