ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2015
Adenovirus-mediated interleukin-35 gene transfer suppresses allergic airway inflammation in a murine model of asthma.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Interleukin-35 as a key immunoregulatory mediator in steroid-hyporesponsive severe asthma.Frontiers in immunology · 2026Review
- IL-35 promotes IL-35Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- Interplay of IL-33 and IL-35 Modulates Th2/Th17 Responses in Cigarette Smoke Exposure HDM-Induced Asthma.Inflammation · 2024Article
- IL35 attenuated LPS-induced acute lung injury by regulating macrophage polarization.Molecular biology reports · 2022Article
- Anti-inflammatory roles of interleukin-35 in the pathogenesis of Japanese cedar pollinosis.Asia Pacific allergy · 2021Article
- Immunomodulatory cytokine interleukin-35 and immune thrombocytopaenia.The Journal of international medical research · 2020Review
- Aberrant Th2 Immune Responses Are Associated With a Reduced Frequency of IL-35-Induced Regulatory T Cells After Allergen Exposure in Patients With Allergic Asthma.Allergy, asthma & immunology research · 2020Article
- LncRNA-AK149641 associated with airway inflammation in an OVA-induced asthma mouse model.Journal of bioenergetics and biomembranes · 2020Article
- Interleukin-35 sensitizes monocytes from patients with asthma to glucocorticoid therapy by regulating p38 MAPK.Experimental and therapeutic medicine · 2020Article
- Different expression levels of interleukin-35 in asthma phenotypes.Respiratory research · 2020Article
- Interleukin-35 reduces inflammation in acute lung injury through inhibiting TLR4/NF-κB signaling pathways.Experimental and therapeutic medicine · 2020Article
- Review
- Regulatory cytokine function in the respiratory tract.Mucosal immunology · 2019Review
- IL-35 interferes with splenic T cells in a clinical and experimental model of acute respiratory distress syndrome.International immunopharmacology · 2019Article
- Intranasal administration of IL-35 inhibits allergic responses and symptoms in mice with allergic rhinitis.Allergology international : official journal of the Japanese Society of Allergology · 2017Article
- Role of Anti-inflammatory Cytokines IL-35 and IL-37 in Asthma.Inflammation · 2017Review
- Interleukin-35: a Potential Therapeutic Agent for Autoimmune Diseases.Inflammation · 2017Review
- The renal level of a novel cytokine IL-35 is related to sepsis-associated acute kidney injury in mice.International journal of clinical and experimental pathology · 2017Article
- Interluekin-35 in Asthma and Its Potential as an Effective Therapeutic Agent.Mediators of inflammation · 2017Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE AND
designAsthma is thought to result from the generation of T helper type 2 (Th2) responses, leading to bronchial inflammation. Interleukin (IL)-35 is a recently described member of IL-12 cytokine family that plays a critical role in influencing Th cell differentiation and inflammatory processes. The aim of this study was to examine the effect of adenovirus expressing IL-35 (AdIL-35) on allergic airway hyperresponsiveness (AHR) and inflammation in a mouse model of asthma.
methodsBALB/c mice were subjected to an established model of allergic airway disease. AdIL-35 was administered intranasally and the effect of IL-35 on Th2 responses, pulmonary inflammation, goblet cell metaplasia, and AHR were assessed.
resultsTransfer of AdIL-35 significantly reduced the severity of AHR and numbers of inflammatory cells and levels of IL-4, IL-5, IL-13, and IL-17 in bronchoalveolar lavage fluid, compared with administration of a control virus. Moreover, AdIL-35 elevated the numbers of CD4+CD25+Foxp3+ regulatory T cells in the lungs. Histological analysis showed that AdIL-35 inhibited allergic lung tissue inflammation and mucus hypersecretion.
conclusionThese results demonstrate that adenovirus-mediated delivery of interleukin-35 gene can mitigate allergic airway inflammation in experimental asthma and suggest that IL-35 may offer a novel therapeutic approach to treat allergic asthma.
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Registered trials
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