ArticleBiomaterials2015
Biological and MRI characterization of biomimetic ECM scaffolds for cartilage tissue regeneration.
Article in Biomaterials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration.TheScientificWorldJournal · 2017Pooled it
- Dynamic monitoring soft tissue healing via visualized Gd-crosslinked double network MRI microspheres.Journal of nanobiotechnology · 2024Article
- Articular cartilage repair biomaterials: strategies and applications.Materials today. Bio · 2024Review
- Effect of autologous lyophilized platelet‑rich fibrin on the reconstruction of osteochondral defects in rabbits.Experimental and therapeutic medicine · 2023Article
- Photo-crosslinked bioactive BG/BMSCs@GelMA hydrogels for bone-defect repairs.Materials today. Bio · 2023Article
- Article
- Modulating the surface potential of microspheres by phase transition in strontium doped barium titanate to restore the electric microenvironment for bone regeneration.Frontiers in bioengineering and biotechnology · 2022Article
- Infrapatellar Fat Pads-Derived Stem Cell Is a Favorable Cell Source for Articular Cartilage Tissue Engineering: AnCartilage · 2021Article
- Article
- Bioprintability: Physiomechanical and Biological Requirements of Materials for 3D Bioprinting Processes.Polymers · 2020Review
- Evaluating the Endocytosis and Lineage-Specification Properties of Mesenchymal Stem Cell Derived Extracellular Vesicles for Targeted Therapeutic Applications.Frontiers in pharmacology · 2020Article
- Cartilage Extracellular Matrix Scaffold With Kartogenin-Encapsulated PLGA Microspheres for Cartilage Regeneration.Frontiers in bioengineering and biotechnology · 2020Article
- Effects of culture conditions on the mechanical and biological properties of engineered cartilage constructed with collagen hybrid scaffold and human mesenchymal stem cells.Journal of materials science. Materials in medicine · 2019Article
- Preparation of an acellular spinal cord scaffold to improve its biological properties.Molecular medicine reports · 2019Article
- Imaging Biomaterial-Tissue Interactions.Trends in biotechnology · 2018Review
- Mesenchymal stem cell-derived extracellular matrix enhances chondrogenic phenotype of and cartilage formation by encapsulated chondrocytes in vitro and in vivo.Acta biomaterialia · 2018Article
- Dual ECM Biomimetic Scaffolds for Dental Pulp Regenerative Applications.Frontiers in physiology · 2018Article
- Noninvasive Absolute Electron Paramagnetic Resonance Oxygen Imaging for the Assessment of Tissue Graft Oxygenation.Tissue engineering. Part C, Methods · 2018Article
- Temporal development of near-native functional properties and correlations with qMRI in self-assembling fibrocartilage treated with exogenous lysyl oxidase homolog 2.Acta biomaterialia · 2017Article
- 3D-printed porous titanium changed femoral head repair growth patterns: osteogenesis and vascularisation in porous titanium.Journal of materials science. Materials in medicine · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Osteoarthritis is the most common joint disorder affecting millions of people. Most scaffolds developed for cartilage regeneration fail due to vascularization and matrix mineralization. In this study we present a chondrogenic extracellular matrix (ECM) incorporated collagen/chitosan scaffold (chondrogenic ECM scaffold) for potential use in cartilage regenerative therapy. Biochemical characterization showed that these scaffolds possess key pro-chondrogenic ECM components and growth factors. MRI characterization showed that the scaffolds possess mechanical properties and diffusion characteristics important for cartilage tissue regeneration. In vivo implantation of the chondrogenic ECM scaffolds with bone marrow derived mesenchymal stem cells (MSCs) triggered chondrogenic differentiation of the MSCs without the need for external stimulus. Finally, results from in vivo MRI experiments indicate that the chondrogenic ECM scaffolds are stable and possess MR properties on par with native cartilage. Based on our results, we envision that such ECM incorporated scaffolds have great potential in cartilage regenerative therapy. Additionally, our validation of MR parameters with histology and biochemical analysis indicates the ability of MRI techniques to track the progress of our ECM scaffolds non-invasively in vivo; highlighting the translatory potential of this technology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.