Evidence map›Paper›PMID 26318431›Full record

ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016

Genome-wide haplotype association analysis identifies SERPINB9, SERPINE2, GAK, and HSP90B1 as novel risk genes for oral squamous cell carcinoma.

Wei Sun, Wenhua Lv, Hongchao Lv, Ruijie Zhang, Yongshuai Jiang

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Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. miR-206 inhibits renal cell cancer growth by targeting GAK.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wei SunCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150086, China.
Wenhua LvCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150086, China.
Hongchao LvCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150086, China.
Ruijie ZhangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150086, China. zhangruijie2013@gmail.com.
Yongshuai JiangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150086, China. jiangyongshuai@gmail.com.
Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The oral squamous cell carcinoma (OSCC) is one of the most common malignant epithelial neoplasms and considered to be caused by the genetic damage. In addition, smoking habit and excessive alcohol consumption have been estimated to be the main risk factors. Although the association between OSCC and genetic susceptibility loci has been observed in many different populations, most of these studies simply focused on the single nucleotide polymorphism. Therefore, we made a contrast analysis between the 112 OSCC patients from the GEO database and 245 normal samples from the HapMap project. First, we performed a genome-wide haplotype association study by comparing the frequency of the haplotypes in the case-control experiment. Then, we mapped the haplotypes to the corresponding genes, screened the risk genes according to significant haplotypes (P < 1E-04), and prioritized the OSCC genes based on their similarity to the known OSCC susceptibility genes. We filtered four OSCC genes including SERPINB9, SERPINE2, GAK, and HSP90B1 through the gene global prioritization score (P < 0.005). SERPINB9 ranked first in the candidate gene list and contained a significant haplotype TAGGA (P value = 3.12E-11). The second risk gene was SERPINE2 with the haplotype GGGCCCTTT, which was closely similar to the SERPINB9.

Indexed as

Alcohol DrinkingCarcinoma, Squamous CellCase-Control StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyHaplotypesHumansIntracellular Signaling Peptides and ProteinsMembrane GlycoproteinsMouth NeoplasmsPolymorphism, Single NucleotideProtein Serine-Threonine KinasesRisk FactorsSerpin E2SerpinsSmokingendoplasminGAK protein, humanIntracellular Signaling Peptides and ProteinsMembrane GlycoproteinsProtein Serine-Threonine KinasesSERPINB9 protein, humanSerpin E2SERPINE2 protein, humanSerpinsAssociation studyHaplotypeOSCCRisk gene

Identifiers

PMID26318431
OpenAlexW1826754102

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.