ArticleMolecular biology and evolution2015
Family Wide Molecular Adaptations to Underground Life in African Mole-Rats Revealed by Phylogenomic Analysis.
Article in Molecular biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 65 citations in OpenAlex.
- The genomic basis of independent marine transitions in turtles: convergent episodic adaptation and demographic shifts.Molecular biology and evolution · 2026Article
- De novo genome assembly of Ansell's mole-rat (Fukomys anselli).G3 (Bethesda, Md.) · 2026Article
- Evolutionary patterns in squamate mitogenomes: Are selective regimes associated with fossoriality and limblessness?Genetics and molecular biology · 2026Article
- Molecular Characterization of Hypothalamic-Pituitary-Ovarian Axis Regulation in the Manchurian Zokor (Genes · 2025Article
- Genomic structural variation is associated with hypoxia adaptation in high-altitude zokors.Nature ecology & evolution · 2024Article
- Evolution of high-molecular-mass hyaluronic acid is associated with subterranean lifestyle.Nature communications · 2023Article
- Phylogenetic modeling of enhancer shifts in African mole-rats reveals regulatory changes associated with tissue-specific traits.Genome research · 2023Article
- Transcriptome mining extends the host range of theVirus evolution · 2023Article
- Genomic insight into the nocturnal adaptation of the black-crowned night heron (Nycticorax nycticorax).BMC genomics · 2022Article
- Convergent evolution of a genomic rearrangement may explain cancer resistance in hystrico- and sciuromorpha rodents.NPJ aging and mechanisms of disease · 2021Article
- Dietary Diversification and Specialization in Neotropical Bats Facilitated by Early Molecular Evolution.Molecular biology and evolution · 2021Article
- Alternative Animal Models of Aging Research.Frontiers in molecular biosciences · 2021Review
- Functional, Morphological, and Evolutionary Characterization of Hearing in Subterranean, Eusocial African Mole-Rats.Current biology : CB · 2020Article
- GBA3: a polymorphic pseudogene in humans that experienced repeated gene loss during mammalian evolution.Scientific reports · 2020Article
- The use of non-traditional models in the study of cancer resistance-the case of the naked mole rat.Oncogene · 2020Review
- Independent evolution of pain insensitivity in African mole-rats: origins and mechanisms.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Review
- Article
- What lies beneath? Molecular evolution during the radiation of caecilian amphibians.BMC genomics · 2019Article
- Phylogeny and biogeography of the African Bathyergidae: a review of patterns and processes.PeerJ · 2019Article
- As Blind as a Bat? Opsin Phylogenetics Illuminates the Evolution of Color Vision in Bats.Molecular biology and evolution · 2019Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
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Abstract
During their evolutionary radiation, mammals have colonized diverse habitats. Arguably the subterranean niche is the most inhospitable of these, characterized by reduced oxygen, elevated carbon dioxide, absence of light, scarcity of food, and a substrate that is energetically costly to burrow through. Of all lineages to have transitioned to a subterranean niche, African mole-rats are one of the most successful. Much of their ecological success can be attributed to a diet of plant storage organs, which has allowed them to colonize climatically varied habitats across sub-Saharan Africa, and has probably contributed to the evolution of their diverse social systems. Yet despite their many remarkable phenotypic specializations, little is known about molecular adaptations underlying these traits. To address this, we sequenced the transcriptomes of seven mole-rat taxa, including three solitary species, and combined new sequences with existing genomic data sets. Alignments of more than 13,000 protein-coding genes encompassed, for the first time, all six genera and the full spectrum of ecological and social variation in the clade. We detected positive selection within the mole-rat clade and along ancestral branches in approximately 700 genes including loci associated with tumorigenesis, aging, morphological development, and sociality. By combining these results with gene ontology annotation and protein-protein networks, we identified several clusters of functionally related genes. This family wide analysis of molecular evolution in mole-rats has identified a suite of positively selected genes, deepening our understanding of the extreme phenotypic traits exhibited by this group.
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