Evidence map›Paper›PMID 26318288›Full record

ArticleBehavior genetics2016

G×E Interaction Influences Trajectories of Hand Grip Strength.

Inge Petersen, Nancy L Pedersen, Taina Rantanen, William S Kremen, Wendy Johnson, Matthew S Panizzon, Lene Christiansen, Carol E Franz, Matt McGue, Kaare Christensen and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavior genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019
    Trial
  2. Article
  3. The Interplay of Genes and Environment Across Multiple Studies (IGEMS) Consortium After Fifteen Years.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2026
    Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 5 countries.

Inge PetersenThe Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark. ipetersen@health.sdu.dk.ORCID http://orcid.org/0000-0001-8057-8336
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Taina RantanenGerontology Research Center and Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
William S KremenDepartment of Psychiatry and Center for Behavioral Genomics, University of California, San Diego, La Jolla, CA, USA.
Wendy JohnsonDepartment of Psychology and Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Matthew S PanizzonDepartment of Psychiatry and Center for Behavioral Genomics, University of California, San Diego, La Jolla, CA, USA.
Lene ChristiansenThe Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
Carol E FranzDepartment of Psychiatry and Center for Behavioral Genomics, University of California, San Diego, La Jolla, CA, USA.
Matt McGueThe Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
Kaare ChristensenThe Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
Nayla R HamdiDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Robert F KruegerDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Chandra ReynoldsDepartment of Psychology, University of California - Riverside, Riverside, CA, USA.
University of California San Diego · USUniversity of Minnesota · USUniversity of Southern Denmark · DKKarolinska Institutet · SEUniversity of California, Riverside · USUniversity of Edinburgh · GBUniversity of Jyväskylä · FI

Funding

U19 MIDlife in the United States-Diversity Supplement-WellsU19AG051426 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CAROL D. RYFF · 2016 to 2026
$74.8M
STATISTICS COREP01AG020166 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI RYFF, CAROL D. · 2002 to 2015
$50.6M
The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0M
The VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3M
TRAJECTORIES OF MORTALITY IN CAENORHABDITIS ELEGANSP01AG008761 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ROACH, DEBORAH A · 1990 to 2008
$17.5M
The VETSA Longitudinal Twin Study of Cognition and AgingR01AG018384 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LYONS, MICHAEL J. · 2002 to 2012
$9.8M
The VETSA longitudinal twin study of cognition and agingR01AG018386 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2002 to 2012
$9.7M
Gene-Environment Interplay of Social Contexts and Aging-Related OutcomesR01AG037985 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PEDERSEN, NANCY L · 2010 to 2014
$3.2M
GENETIC &ENVIRONMENTAL INFLUENCES--BIOBEHAVIORAL AGINGR01AG010175 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PEDERSEN, NANCY L · 1992 to 2006
$2.8M
The VETSA Longitudinal Twin Study of Cortisol and AgingR01AG022982 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2004 to 2007
$2.6M
ORIGINS OF VARIANCE IN THE OLD-OLD: OCTOGENARIAN TWINSR01AG008861 · NIA · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI MCCLEARN, GERALD E · 1990 to 1993
–
GENETIC AND ENVIRONMENTAL INFLUENCES IN BEHAVIORAL AGINGR01AG004563 · NIA · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI MCCLEARN, GERALD E · 1985 to 1988
–
Medical Research Council MR/K026992/1NIA NIH HHS AG20166NIA NIH HHS P01 AG008761NIA NIH HHS P01 AG020166NIA NIH HHS P01 AG08761NIA NIH HHS R01 AG010175NIA NIH HHS R01 AG018384NIA NIH HHS R01 AG018386NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG022982NIA NIH HHS R01 AG037985NIA NIH HHS R01 AG04563NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG08861NIA NIH HHS R01 AG10175NIA NIH HHS U19 AG051426
6 · The paper itself

Abstract

Age-related decline in grip strength predicts later life disability, frailty, lower well-being and cognitive change. While grip strength is heritable, genetic influence on change in grip strength has been relatively ignored, with non-shared environmental influence identified as the primary contributor in a single longitudinal study. The extent to which gene-environment interplay, particularly gene-environment interactions, contributes to grip trajectories has yet to be examined. We considered longitudinal grip strength measurements in seven twin studies of aging in the Interplay of Genes and Environment across Multiple Studies consortium. Growth curve parameters were estimated for same-sex pairs, aged 34-99 (N = 10,681). Fisher's test for mixture distribution of within-monozygotic twin-pair differences (N = 1724) was performed on growth curve parameters. We observed significant gene-environment interaction on grip strength trajectories. Finally, we compared the variability of within-pair differences of growth curve parameters by APOE haplotypes. Though not statistically significant, the results suggested that APOE ɛ2ɛ2/ɛ2ɛ3 haplotypes might buffer environmental influences on grip strength trajectories.

Indexed as

AdultAgedAged, 80 and overAge FactorsAgingApolipoproteins EEnvironmentFemaleGene-Environment InteractionHand StrengthHumansLongitudinal StudiesMaleMiddle AgedTwins, MonozygoticApolipoproteins EAPOEGene-environment interactionGrip strengthTwins

Identifiers

PMID26318288
PMCPMC4720577
OpenAlexW1892656798

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.