ReviewMethods (San Diego, Calif.)2016
Pushing, pulling, and squeezing our way to understanding mechanotransduction.
Review in Methods (San Diego, Calif.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Actuated 3D microgels for single cell mechanobiology.Lab on a chip · 2022Article
- An Easy-to-Fabricate Cell Stretcher Reveals Density-Dependent Mechanical Regulation of Collective Cell Movements in Epithelia.Cellular and molecular bioengineering · 2021Article
- Review
- Computational 4D-OCM for label-free imaging of collective cell invasion and force-mediated deformations in collagen.Scientific reports · 2021Article
- Active biomaterials for mechanobiology.Biomaterials · 2021Review
- Mechanobiology Assays with Applications in Cardiomyocyte Biology and Cardiotoxicity.Advanced healthcare materials · 2020Review
- Binding partner- and force-promoted changes in αE-catenin conformation probed by native cysteine labeling.Scientific reports · 2019Article
- Brillouin microscopy: an emerging tool for mechanobiology.Nature methods · 2019Review
- Mechanotransduction in neuronal cell development and functioning.Biophysical reviews · 2019Review
- Quantitative reconstruction of time-varying 3D cell forces with traction force optical coherence microscopy.Scientific reports · 2019Article
- Mechanotransduction in tumor progression: The dark side of the force.The Journal of cell biology · 2018Review
- Cell-cell adhesion interface: orthogonal and parallel forces from contraction, protrusion, and retraction.F1000Research · 2018Review
- Microfluidics for mechanobiology of model organisms.Methods in cell biology · 2018Article
- E-cadherin and LGN align epithelial cell divisions with tissue tension independently of cell shape.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Taking the strain: quantifying the contributions of all cell behaviours to changes in epithelial shape.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Microfabricated tissues for investigating traction forces involved in cell migration and tissue morphogenesis.Cellular and molecular life sciences : CMLS · 2017Review
- Measurement of dynamic cell-induced 3D displacement fieldsBiomedical optics express · 2017Article
- Combined optical micromanipulation and interferometric topography (COMMIT).Biomedical optics express · 2016Article
- Traction Force Microscopy for Noninvasive Imaging of Cell Forces.Advances in experimental medicine and biologyReview
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Mechanotransduction is often described in the context of force-induced changes in molecular conformation, but molecular-scale mechanical stimuli arise in vivo in the context of complex, multicellular tissue structures. For this reason, we highlight and review experimental methods for investigating mechanotransduction across multiple length scales. We begin by discussing techniques that probe the response of individual molecules to applied force. We then move up in length scale to highlight techniques aimed at uncovering how cells transduce mechanical stimuli into biochemical activity. Finally, we discuss approaches for determining how these stimuli arise in multicellular structures. We expect that future work will combine techniques across these length scales to provide a more comprehensive understanding of mechanotransduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.