ArticleJournal of industrial microbiology & biotechnology2016
Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery.
Article in Journal of industrial microbiology & biotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Advances in the Study of Halogenated Natural Products.Current topics in medicinal chemistry · 2025Review
- Primed for Discovery.Biochemistry · 2024Review
- Enediyne natural product biosynthesis unified by a diiodotetrayne intermediate.Nature chemical biology · 2024Article
- Genome mining for new enediyne antibiotics.Current opinion in chemical biology · 2024Review
- Pseudogenomic insights into the evolution of Mycobacterium ulcerans.BMC genomics · 2024Article
- Targeted Discovery of Cryptic Enediyne Natural Products via FRET-Coupled High-Throughput Elicitor Screening.ACS chemical biology · 2023Article
- Article
- Expression ofApplied and environmental microbiology · 2023Article
- A discrete intermediate for the biosynthesis of both the enediyne core and the anthraquinone moiety of enediyne natural products.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Resistance and phylogeny guided discovery reveals structural novelty of tetracycline antibiotics.Chemical science · 2022Article
- Multispecies Populations of MethanotrophicApplied and environmental microbiology · 2022Article
- Great diversity of KSFEMS microbes · 2022Article
- Genome mining methods to discover bioactive natural products.Natural product reports · 2021Review
- Comparative genomic analysis of azasugar biosynthesis.AMB Express · 2021Article
- Review
- Mining and unearthing hidden biosynthetic potential.Nature communications · 2021Review
- Submerged fermentation of Streptomyces uncialis providing a biotechnology platform for uncialamycin biosynthesis, engineering, and production.Journal of industrial microbiology & biotechnology · 2021Article
- Challenges and Opportunities to Develop Enediyne Natural Products as Payloads for Antibody-Drug Conjugates.Antibody therapeutics · 2021Article
- PhotoModPlus: A web server for photosynthetic protein prediction from genome neighborhood features.PloS one · 2021Article
- Targeting Bacterial Genomes for Natural Product Discovery.Trends in pharmacological sciences · 2020Review
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Authors and funding
3 authors.
Funding
Abstract
The enediynes are one of the most fascinating families of bacterial natural products given their unprecedented molecular architecture and extraordinary cytotoxicity. Enediynes are rare with only 11 structurally characterized members and four additional members isolated in their cycloaromatized form. Recent advances in DNA sequencing have resulted in an explosion of microbial genomes. A virtual survey of the GenBank and JGI genome databases revealed 87 enediyne biosynthetic gene clusters from 78 bacteria strains, implying that enediynes are more common than previously thought. Here we report the construction and analysis of an enediyne genome neighborhood network (GNN) as a high-throughput approach to analyze secondary metabolite gene clusters. Analysis of the enediyne GNN facilitated rapid gene cluster annotation, revealed genetic trends in enediyne biosynthetic gene clusters resulting in a simple prediction scheme to determine 9- versus 10-membered enediyne gene clusters, and supported a genomic-based strain prioritization method for enediyne discovery.
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