ArticlePLoS genetics2015
The Relationship between Gene Network Structure and Expression Variation among Individuals and Species.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Splicing is dynamically regulated during limb development.Scientific reports · 2024Article
- Postnatal development in a marsupial model, the fat-tailed dunnart (Sminthopsis crassicaudata; Dasyuromorphia: Dasyuridae).Communications biology · 2021Article
- Non-model systems in mammalian forelimb evo-devo.Current opinion in genetics & development · 2021Review
- X chromosome-dependent disruption of placental regulatory networks in hybrid dwarf hamsters.Genetics · 2021Article
- Article
- Gene Regulatory and Expression Differences between Mouse and Pig Limb Buds Provide Insights into the Evolutionary Emergence of Artiodactyl Traits.Cell reports · 2020Article
- Gene Network Analysis of Interstitial Macrophages After Treatment with Induced Pluripotent Stem Cells Secretome (iPSC-cm) in the Bleomycin Injured Rat Lung.Stem cell reviews and reports · 2018Article
- Limb development: a paradigm of gene regulation.Nature reviews. Genetics · 2017Review
- Transcriptomic insights into the genetic basis of mammalian limb diversity.BMC evolutionary biology · 2017Article
- A new developmental mechanism for the separation of the mammalian middle ear ossicles from the jaw.Proceedings. Biological sciences · 2017Article
- Cellular and molecular drivers of differential organ growth: insights from the limbs of Monodelphis domestica.Development genes and evolution · 2016Article
- Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Variation among individuals is a prerequisite of evolution by natural selection. As such, identifying the origins of variation is a fundamental goal of biology. We investigated the link between gene interactions and variation in gene expression among individuals and species using the mammalian limb as a model system. We first built interaction networks for key genes regulating early (outgrowth; E9.5-11) and late (expansion and elongation; E11-13) limb development in mouse. This resulted in an Early (ESN) and Late (LSN) Stage Network. Computational perturbations of these networks suggest that the ESN is more robust. We then quantified levels of the same key genes among mouse individuals and found that they vary less at earlier limb stages and that variation in gene expression is heritable. Finally, we quantified variation in gene expression levels among four mammals with divergent limbs (bat, opossum, mouse and pig) and found that levels vary less among species at earlier limb stages. We also found that variation in gene expression levels among individuals and species are correlated for earlier and later limb development. In conclusion, results are consistent with the robustness of the ESN buffering among-individual variation in gene expression levels early in mammalian limb development, and constraining the evolution of early limb development among mammalian species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.