ArticlePloS one2015
Mortality Prediction in the Oldest Old with Five Different Equations to Estimate Glomerular Filtration Rate: The Health and Anemia Population-based Study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 34 citations in OpenAlex.
- A Systematic Review Comparing the Prognostic Role of eGFR According to CKD-EPI and Older Age Validated Equations in Older Adults.Kidney medicine · 2025Article
- Development and Validation of a Novel Risk Score for All-Cause Mortality Risk Stratification Prior to Permanent Pacemaker Implantation in Octogenarians or Older.Medicina (Kaunas, Lithuania) · 2023Article
- Does Estimated Glomerular Filtration Rate Predict In-Hospital Mortality in Acutely Unwell Hospitalized Oldest Old?Geriatrics (Basel, Switzerland) · 2022Article
- The role of kidney dysfunction in COVID-19 and the influence of age.Scientific reports · 2022Article
- Kidney Function According to Different Equations in Patients Admitted to a Cardiology Unit and Impact on Outcome.Journal of clinical medicine · 2022Article
- The predictive value of creatinine clearance for mortality in patients undergoing revascularization.Journal of cardiothoracic surgery · 2021Article
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- Endovascular abdominal aortic aneurysm repair in a centenarian.Journal of vascular surgery cases and innovative techniques · 2020Article
- Kidney function and cognitive impairment among older hospitalized patients: a comparison of four glomerular filtration rate equations.Aging clinical and experimental research · 2020Article
- Longitudinal Changes in Kidney Function Estimated from Cystatin C and Its Association with Mortality in Elderly Women.Nephron · 2020Article
- Comparative Performance of Creatinine-Based GFR Estimation Equations in Exceptional Longevity: The Rugao Longevity and Ageing Study.Clinical interventions in aging · 2020Article
- Cystatin C and creatinine-based eGFR levels and their correlation to long-term morbidity and mortality in older adults.Aging clinical and experimental research · 2019Article
- Low thyroid function is not associated with an accelerated deterioration in renal function.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2019Article
- Predicting survival of older community-dwelling individuals according to five estimated glomerular filtration rate equations: The InChianti study.Geriatrics & gerontology international · 2018Article
- Article
- Agreement between Chronic Kidney Disease Epidemiological Collaboration and Berlin Initiative Study equations for estimating glomerular filtration rate in older people: The Invecchiare in Chianti (Aging in Chianti Region) study.Geriatrics & gerontology international · 2017Article
- The global burden of chronic kidney disease: estimates, variability and pitfalls.Nature reviews. Nephrology · 2017Review
- Renal Function and Death in Older Women: Which eGFR Formula Should We Use?International journal of nephrology · 2017Article
- Article
- Operationalizing a frailty index using routine blood and urine tests.Clinical interventions in aging · 2017Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKidney function declines considerably with age, but little is known about its clinical significance in the oldest-old.
objectivesTo study the association between reduced glomerular filtration rate (GFR) estimated according to five equations with mortality in the oldest-old.
designProspective population-based study.
settingMunicipality of Biella, Piedmont, Italy.
participants700 subjects aged 85 and older participating in the "Health and Anemia" Study in 2007-2008. MEASUREMENTS: GFR was estimated using five creatinine-based equations: the Cockcroft-Gault (C-G), Modification of Diet in Renal Disease (MDRD), MAYO Clinic, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Berlin Initiative Study-1 (BIS-1). Survival analysis was used to study mortality in subjects with reduced eGFR (<60 mL/min/1.73 m(2)) compared to subjects with eGFR ≥ 60 mL/min/1.73 m(2).
resultsPrevalence of reduced GFR was 90.7% with the C-G, 48.1% with MDRD, 23.3% with MAYO, 53.6% with CKD-EPI and 84.4% with BIS-1. After adjustment for confounders, two-year mortality was significantly increased in subjects with reduced eGFR using BIS-1 and C-G equations (adjusted HRs: 2.88 and 3.30, respectively). Five-year mortality was significantly increased in subjects with eGFR <60 mL/min/1.73 m(2) using MAYO, CKD-EPI and, in a graduated fashion in reduced eGFR categories, MDRD. After 5 years, oldest old with an eGFR <30 mL/min/1.73 m(2) showed a significantly higher risk of death whichever equation was used (adjusted HRs between 2.04 and 2.70).
conclusionIn the oldest old, prevalence of reduced eGFR varies noticeably depending on the equation used. In this population, risk of mortality was significantly higher for reduced GFR estimated with the BIS-1 and C-G equations over the short term. Though after five years the MDRD appeared on the whole a more consistent predictor, differences in mortality prediction among equations over the long term were less apparent. Noteworthy, subjects with a severely reduced GFR were consistently at higher risk of death regardless of the equation used to estimate GFR.
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