ArticlePloS one2015
Time Trends in Epidemiologic Characteristics and Imaging Features of Lung Adenocarcinoma: A Population Study of 21,113 Cases in China.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- A lung cancer risk prediction model for nonsmokers: A retrospective analysis of lung nodule cohorts in China.Journal of clinical laboratory analysis · 2022Article
- Establishing a Novel Gene Signature Related to Histone Modifications for Predicting Prognosis in Lung Adenocarcinoma.Journal of oncology · 2022Article
- PRKCA Overexpression Is Frequent in Young Oral Tongue Squamous Cell Carcinoma Patients and Is Associated with Poor Prognosis.Cancers · 2021Article
- Article
- Construction and Analysis of Survival-Associated Competing Endogenous RNA Network in Lung Adenocarcinoma.BioMed research international · 2021Article
- Solid component ratio influences prognosis of GGO-featured IA stage invasive lung adenocarcinoma.Cancer imaging : the official publication of the International Cancer Imaging Society · 2020Article
- Dual-energy computed tomography for pre-surgical identification of adenocarcinoma subtypes.Translational lung cancer research · 2020Article
- Dual-energy spectral CT characteristics in surgically resected lung adenocarcinoma: comparison between Kirsten rat sarcoma viral oncogene mutations and epidermal growth factor receptor mutations.Cancer imaging : the official publication of the International Cancer Imaging Society · 2019Article
- HDGF and PRKCA upregulation is associated with a poor prognosis in patients with lung adenocarcinoma.Oncology letters · 2019Article
- Decoding tumor mutation burden and driver mutations in early stage lung adenocarcinoma using CT-based radiomics signature.Thoracic cancer · 2019Article
- Long Noncoding RNA SBF2-AS1 Is Critical for Tumorigenesis of Early-Stage Lung Adenocarcinoma.Molecular therapy. Nucleic acids · 2019Article
- Identification of epidermal growth factor receptor mutations in pulmonary adenocarcinoma using dual-energy spectral computed tomography.European radiology · 2019Article
- [Expression of hUTP14a in non-small cell lung cancer].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2019Article
- Low Expression of ASK1-Interacting Protein-1 Is Significantly Correlated with Tumor Angiogenesis and Poor Survival in Patients with Early Stage Non-Small Cell Lung Cancer.OncoTargets and therapy · 2019Article
- Analysis of the clinicopathological characteristics and their trends among patients with lung cancer undergoing surgery in a tertiary cancer hospital of north China during 2000-2013.Journal of thoracic disease · 2018Article
- Solid component proportion is an important predictor of tumor invasiveness in clinical stage TCancer imaging : the official publication of the International Cancer Imaging Society · 2018Article
- [A Retrospective Study of Mean Computed Tomography Value to Predict the Tumor Invasiveness in AAH and Clinical Stage Ia Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2018Article
- Pathologic NScientific reports · 2017Article
- [Effect of Smoking on Lung Cancer Histology and Its Epidemiology in Chinese Male].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2017Article
- Clinical profiles and trend analysis of newly diagnosed lung cancer in a tertiary care hospital of East China during 2011-2015.Journal of thoracic disease · 2017Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aims to describe time trends of epidemiologic characteristics and imaging features over 14 years among histologically confirmed lung adenocarcinoma (ADC) in China and to discuss the possible reasons for these changes. MATERIALS AND
methodsData of 21,113 pathologically confirmed lung cancer patients from January 1999 to December 2012 were analyzed retrospectively. Preoperative high-resolution computer tomography (HRCT) images were available and reviewed in 5,439 lung ADC patients since 2005. Time trends of the ADC proportion of lung cancer cases, gender distribution, age at diagnosis, the proportion of early-stage ADC and imaging features were investigated.
resultsThe proportion of ADC increased during the 14 years (P = 0.000). The ratio of female to male ADC cases was higher than both squamous cell carcinoma (SQCC) and total lung cancer cases (P = 0.000). The median age at diagnosis of ADC patients was younger than that of both SQCC and total lung cancer during the 14 years (P = 0.000). The proportion of age group 45-59 years increased in total lung cancer cases (P = 0.000). When stratified by lung cancer histopathologic subtypes, this trend was also observed in ADC (P = 0.001) and SQCC (P = 0.007). The proportion of early-stage cases of ADC increased from 2008 to 2012 (P < 0.001). The proportion of subsolid nodules (SSN) in ADC increased (P = 0.001) from 2005 to 2012.
conclusionThe data suggests that the proportion of ADC increased from 1999 to 2012 especially in middle-aged, female patients; early-stage ADC and SSN on HRCT images gradually increased, which may have been caused by a change in smoking habits and increased application of HRCT.
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