Evidence map›Paper›PMID 26317832›Full record

ArticlePloS one2015

Dietary Tributyrin Supplementation Attenuates Insulin Resistance and Abnormal Lipid Metabolism in Suckling Piglets with Intrauterine Growth Retardation.

Jintian He, Li Dong, Wen Xu, Kaiwen Bai, Changhui Lu, Yanan Wu, Qiang Huang, Lili Zhang, Tian Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Effects of Inclusion of Different Doses ofAnimals : an open access journal from MDPI · 2020
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jintian HeCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu, People's Republic of China.
Li DongCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu, People's Republic of China.
Wen XuCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu, People's Republic of China.
Kaiwen BaiCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu, People's Republic of China.
Changhui LuCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu, People's Republic of China.
Yanan WuCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu, People's Republic of China.
Qiang HuangCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu, People's Republic of China.
Lili ZhangCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu, People's Republic of China.
Tian WangCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu, People's Republic of China.
Nanjing Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intrauterine growth retardation (IUGR) is associated with insulin resistance and lipid disorder. Tributyrin (TB), a pro-drug of butyrate, can attenuate dysfunctions in body metabolism. In this study, we investigated the effects of TB supplementation on insulin resistance and lipid metabolism in neonatal piglets with IUGR. Eight neonatal piglets with normal birth weight (NBW) and 16 neonatal piglets with IUGR were selected, weaned on the 7th day, and fed basic milk diets (NBW and IUGR groups) or basic milk diets supplemented with 0.1% tributyrin (IT group, IUGR piglets) until day 21 (n = 8). Relative parameters for lipid metabolism and mRNA expression were measured. Piglets with IUGR showed higher (P < 0.05) concentrations of insulin in the serum, higher (P < 0.05) HOMA-IR and total cholesterol, triglycerides (TG), non-esterified fatty acid (NEFA) in the liver, and lower (P < 0.05) enzyme activities (hepatic lipase [HL], lipoprotein lipase [LPL], total lipase [TL]) and concentration of glycogen in the liver than the NBW group. TB supplementation decreased (P < 0.05) the concentrations of insulin, HOMA-IR, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol in the serum, and the concentrations of TG and NEFA in the liver, and increased (P < 0.05) enzyme activities (HL, LPL, and TL) and concentration of glycogen in the liver of the IT group. The mRNA expression for insulin signal transduction pathway and hepatic lipogenic pathway (including transcription factors and nuclear factors) was significantly (P < 0.05) affected in the liver by IUGR, which was efficiently (P < 0.05) attenuated by diets supplemented with TB. TB supplementation has therapeutic potential for attenuating insulin resistance and abnormal lipid metabolism in IUGR piglets by increasing enzyme activities and upregulating mRNA expression, leading to an early improvement in the metabolic efficiency of IUGR piglets.

Indexed as

Insulin ResistanceAnimalsAnimals, NewbornDietary SupplementsFemaleFetal Growth RetardationGene Expression RegulationInsulinLipid MetabolismLiverMaleSwineTriglyceridesInsulintributyrinTriglycerides

Identifiers

PMID26317832
PMCPMC4552672
OpenAlexW2163818492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.