Evidence map›Paper›PMID 26317549›Full record

ArticleOncotarget2015

Splenocytes derived from young WT mice prevent AD progression in APPswe/PSENldE9 transgenic mice.

Fei Wang, Xueyan Shen, Shuping Li, Long Chen, Yanru Wang, Jie Qin, Guomin Zhou, Yuwen Peng, Xiaoyuan Feng, Ruixi Li and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

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  11. A Perspective on Roles Played by Innate and Adaptive Immunity in the Pathobiology of Neurodegenerative Disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Fei WangDepartment of Anatomy and Histology & Embryology, Shanghai Medical College of Fudan University, Shanghai, P. R. China.
Xueyan ShenDepartment of Anatomy and Histology & Embryology, Shanghai Medical College of Fudan University, Shanghai, P. R. China.
Shuping LiDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, P. R. China.
Long ChenDepartment of Anatomy and Histology & Embryology, Shanghai Medical College of Fudan University, Shanghai, P. R. China.
Yanru WangDepartment of Anatomy and Histology & Embryology, Shanghai Medical College of Fudan University, Shanghai, P. R. China.
Jie QinDepartment of Anatomy and Histology & Embryology, Shanghai Medical College of Fudan University, Shanghai, P. R. China.
Guomin ZhouDepartment of Anatomy and Histology & Embryology, Shanghai Medical College of Fudan University, Shanghai, P. R. China.
Yuwen PengDepartment of Anatomy and Histology & Embryology, Shanghai Medical College of Fudan University, Shanghai, P. R. China.
Xiaoyuan FengDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, P. R. China.
Ruixi LiDepartment of Anatomy and Histology & Embryology, Shanghai Medical College of Fudan University, Shanghai, P. R. China.
Chunmin LiangDepartment of Anatomy and Histology & Embryology, Shanghai Medical College of Fudan University, Shanghai, P. R. China.
Shanghai Medical College of Fudan University · CNHuashan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunosenescence contributes to pathogenesis of Alzheimer's disease (AD) in the elderly. In this study, we explored the effects of young wild type (WT) splenocytes (ySCs) on Alzheimer's disease by transplanting ySCs into APPswe/PSENldE9 transgenic mice. Young WT splenocytes not only prevented AD, but also improved the spatial learning and memory of APPswe/PSENldE9 transgenic mice. Young WT splenocytes enhanced Aβ clearance, decreased astrogliosis and increased systemic growth differentiation factor 11 (GDF11) levels. Splenocytes derived from old AD mouse promoted AD. There was an increased number of regulatory T cells (Tregs) among old AD splenocytes. We suggest that alterations of GDF11 and Tregs are involved in AD progression and that rejuvenation of the immune system is a potential therapeutic strategy in AD.

Indexed as

Cell TransplantationAlzheimer DiseaseAnimalsAstrocytesBehavior, AnimalBone Morphogenetic ProteinsDisease Models, AnimalDisease ProgressionExonsGrowth Differentiation FactorsHumansImmunohistochemistryImmunosenescenceMaleMaze LearningMiceBone Morphogenetic ProteinsGdf11 protein, mouseGrowth Differentiation FactorsPresenilin-1Alzheimer’s diseaseGDF11GerotargetimmunosenescencesplenocytesTreg

Identifiers

PMID26317549
PMCPMC4673234
OpenAlexW2148656065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.