ArticlePloS one2015
Consequences of Location-Dependent Organ of Corti Micro-Mechanics.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 33 citations in OpenAlex.
- High resolution, contrast-enhanced X-ray microscopy of theFrontiers in neuroscience · 2026Article
- Coupled oscillator mechanism extends the amplifying effect of outer hair cells to high frequencies.Scientific reports · 2025Article
- Effectiveness of Outer Hair Cells as Cochlear Amplifier: Coupled Oscillator Models.Research square · 2025Article
- Effectiveness of Outer Hair Cells as Cochlear Amplifier: Coupled Oscillator Models.bioRxiv : the preprint server for biology · 2025Article
- Corti Fluid Is a Medium for Outer Hair Cell Force Transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Asymmetric vibrations in the organ of Corti by outer hair cells measured from excised gerbil cochlea.Communications biology · 2024Article
- Advective mass transport along the cochlear coil.AIP conference proceedings · 2024Article
- Deiters Cells Act as Mechanical Equalizers for Outer Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Stimulus-frequency otoacoustic emissions and middle-ear pressure gains in a finite-element mouse model.The Journal of the Acoustical Society of America · 2022Article
- The impact of targeted ablation of one row of outer hair cells and Deiters' cells on cochlear amplification.Journal of neurophysiology · 2022Article
- Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing.Developmental cell · 2021Article
- A role for tectorial membrane mechanics in activating the cochlear amplifier.Scientific reports · 2020Article
- Power Dissipation in the Cochlea Can Enhance Frequency Selectivity.Biophysical journal · 2019Article
- Probing hair cell's mechano-transduction using two-tone suppression measurements.Scientific reports · 2019Article
- Anisotropic Material Properties of Wild-Type and TectbBiophysical journal · 2019Article
- Cellular cartography of the organ of Corti based on optical tissue clearing and machine learning.eLife · 2019Article
- Cochlear amplification and tuning depend on the cellular arrangement within the organ of Corti.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Forward and Reverse Waves: Modeling Distortion Products in the Intracochlear Fluid Pressure.Biophysical journal · 2018Article
- Hydrostatic measurement and finite element simulation of the compliance of the organ of Corti complex.The Journal of the Acoustical Society of America · 2018Article
- Mitochondrial Calcium Transporters Mediate Sensitivity to Noise-Induced Losses of Hair Cells and Cochlear Synapses.Frontiers in molecular neuroscience · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The cochlea performs frequency analysis and amplification of sounds. The graded stiffness of the basilar membrane along the cochlear length underlies the frequency-location relationship of the mammalian cochlea. The somatic motility of outer hair cell is central for cochlear amplification. Despite two to three orders of magnitude change in the basilar membrane stiffness, the force capacity of the outer hair cell's somatic motility, is nearly invariant over the cochlear length. It is puzzling how actuators with a constant force capacity can operate under such a wide stiffness range. We hypothesize that the organ of Corti sets the mechanical conditions so that the outer hair cell's somatic motility effectively interacts with the media of traveling waves-the basilar membrane and the tectorial membrane. To test this hypothesis, a computational model of the gerbil cochlea was developed that incorporates organ of Corti structural mechanics, cochlear fluid dynamics, and hair cell electro-physiology. The model simulations showed that the micro-mechanical responses of the organ of Corti are different along the cochlear length. For example, the top surface of the organ of Corti vibrated more than the bottom surface at the basal (high frequency) location, but the amplitude ratio was reversed at the apical (low frequency) location. Unlike the basilar membrane stiffness varying by a factor of 1700 along the cochlear length, the stiffness of the organ of Corti complex felt by the outer hair cell remained between 1.5 and 0.4 times the outer hair cell stiffness. The Y-shaped structure in the organ of Corti formed by outer hair cell, Deiters cell and its phalange was the primary determinant of the elastic reactance imposed on the outer hair cells. The stiffness and geometry of the Deiters cell and its phalange affected cochlear amplification differently depending on the location.
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