ArticlePLoS computational biology2015
Analysis of Single Locus Trajectories for Extracting In Vivo Chromatin Tethering Interactions.
Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Single-chromosome dynamics reveals locus-dependent dynamics and chromosome territory orientation.Journal of cell science · 2023Article
- Article
- A guide for single-particle chromatin tracking in live cell nuclei.Cell biology international · 2022Review
- Post-replicative pairing of sister ter regions in Escherichia coli involves multiple activities of MatP.Nature communications · 2020Article
- Structural and Dynamical Signatures of Local DNA Damage in Live Cells.Biophysical journal · 2020Article
- Chromatin Viscoelasticity Measured by Local Dynamic Analysis.Biophysical journal · 2020Article
- Rouse model with transient intramolecular contacts on a timescale of seconds recapitulates folding and fluctuation of yeast chromosomes.Nucleic acids research · 2019Article
- Statistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymers.Nature communications · 2019Article
- From dynamic chromatin architecture to DNA damage repair and back.Nucleus (Austin, Tex.) · 2018Review
- Chromatin and nucleosome dynamics in DNA damage and repair.Genes & development · 2017Review
- Two loci single particle trajectories analysis: constructing a first passage time statistics of local chromatin exploration.Scientific reports · 2017Article
- Transient chromatin properties revealed by polymer models and stochastic simulations constructed from Chromosomal Capture data.PLoS computational biology · 2017Article
- Structural Fluctuations of the Chromatin Fiber within Topologically Associating Domains.Biophysical journal · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
Is it possible to extract tethering forces applied on chromatin from the statistics of a single locus trajectories imaged in vivo? Chromatin fragments interact with many partners such as the nuclear membrane, other chromosomes or nuclear bodies, but the resulting forces cannot be directly measured in vivo. However, they impact chromatin dynamics and should be reflected in particular in the motion of a single locus. We present here a method based on polymer models and statistics of single trajectories to extract the force characteristics and in particular when they are generated by the gradient of a quadratic potential well. Using numerical simulations of a Rouse polymer and live cell imaging of the MAT-locus located on the yeast Saccharomyces cerevisiae chromosome III, we recover the amplitude and the distance between the observed and the interacting monomer. To conclude, the confined trajectories we observed in vivo reflect local interaction on chromatin.
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