ArticlePLoS pathogens2015
Leptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed by Genome Sequencing, Transcriptome Profiling and Co-infection with Leishmania donovani.
Article in PLoS pathogens, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed.
- Baseline Characterization of the Gut Microbiota of Field and Colony Populations ofPathogens (Basel, Switzerland) · 2026Article
- The first RNA viruses detected in a trypanosome.BMC biology · 2026Article
- Blechomonas campbelli from Ctenocephalides felis: in vitro development, thermotolerance, and phylogenetic insights.Memorias do Instituto Oswaldo Cruz · 2026Article
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- Non-parasite genome encoded virus-like RNAs reprogram the pathogenicity of human blood flukes.Nature communications · 2025Article
- Chromosome-level genome assembly of trypanosomatid parasite Lotmaria passim links chromosome duplication and divergence with infection of honey bees.BMC genomics · 2025Article
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- The impact of blood on vector-borne diseases with emphasis on mosquitoes and sand flies.Trends in parasitology · 2025Review
- Multiple and frequent trypanosomatid co-infections of insects: the Cuban case study.Parasitology · 2024Article
- Identification of diverse RNA viruses inVirus evolution · 2024Article
- Genomes ofPathogens (Basel, Switzerland) · 2023Article
- Evolution of RNA viruses in trypanosomatids: new insights from the analysis of Sauroleishmania.Parasitology research · 2023Article
- Shining the spotlight on the neglected: new high-quality genome assemblies as a gateway to understanding the evolution of Trypanosomatidae.BMC genomics · 2023Article
- Parasite Detection in Visceral Leishmaniasis Samples by Dye-Based qPCR Using New Gene Targets ofTropical medicine and infectious disease · 2023Article
- Natural infection withFrontiers in microbiology · 2023Article
- TriTrypDB: An integrated functional genomics resource for kinetoplastida.PLoS neglected tropical diseases · 2023Article
- Bee Trypanosomatids: First Steps in the Analysis of the Genetic Variation and Population Structure of Lotmaria passim, Crithidia bombi and Crithidia mellificae.Microbial ecology · 2022Article
- Detection of Leptomonas seymouri narna-like virus in serum samples of visceral leishmaniasis patients and its possible role in disease pathogenesis.Scientific reports · 2022Article
- Leishmania guyanensis M4147 as a new LRV1-bearing model parasite: Phosphatidate phosphatase 2-like protein controls cell cycle progression and intracellular lipid content.PLoS neglected tropical diseases · 2022Article
- A Stroll Through the History of Monoxenous Trypanosomatids Infection in Vertebrate Hosts.Frontiers in cellular and infection microbiology · 2022Review
8 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The co-infection cases involving dixenous Leishmania spp. (mostly of the L. donovani complex) and presumably monoxenous trypanosomatids in immunocompromised mammalian hosts including humans are well documented. The main opportunistic parasite has been identified as Leptomonas seymouri of the sub-family Leishmaniinae. The molecular mechanisms allowing a parasite of insects to withstand elevated temperature and substantially different conditions of vertebrate tissues are not understood. Here we demonstrate that L. seymouri is well adapted for the environment of the warm-blooded host. We sequenced the genome and compared the whole transcriptome profiles of this species cultivated at low and high temperatures (mimicking the vector and the vertebrate host, respectively) and identified genes and pathways differentially expressed under these experimental conditions. Moreover, Leptomonas seymouri was found to persist for several days in two species of Phlebotomus spp. implicated in Leishmania donovani transmission. Despite of all these adaptations, L. seymouri remains a predominantly monoxenous species not capable of infecting vertebrate cells under normal conditions.
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