Evidence map›Paper›PMID 26317048›Full record

ArticleAdipocyte

Intermuscular and intramuscular adipose tissues: Bad vs. good adipose tissues.

Gary J Hausman, Urmila Basu, Min Du, Melinda Fernyhough-Culver, Michael V Dodson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Adipocyte. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 5 pooled it
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 5 syntheses or guidelines pooled it, 203 citations in OpenAlex.

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  14. Integrative Adipogenic Engineering of Cultured Fat for Cell Based Meat.Comprehensive reviews in food science and food safety · 2026
    Review
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  20. Observational

64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 5 countries.

Gary J HausmanDepartment of Animal and Dairy Science; University of Georgia ; Athens, GA USA.
Urmila BasuDepartment of Agriculture, Food and Nutritional Science; University of Alberta ; Edmonton, AB Canada.
Min DuDepartment of Animal Sciences; Washington State University ; Pullman, WA USA.
Melinda Fernyhough-CulverAbitec Corporation ; Columbus, OH USA.
Michael V DodsonDepartment of Animal Sciences; Washington State University ; Pullman, WA USA.
Washington State University · USAbitec (Czechia) · CZAgriculture and Food · AUPiedmont Athens Regional · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human studies of the influence of aging and other factors on intermuscular fat (INTMF) were reviewed. Intermuscular fat increased with weight loss, weight gain, or with no weight change with age in humans. An increase in INTMF represents a similar threat to type 2 diabetes and insulin resistance as does visceral adipose tissue (VAT). Studies of INTMF in animals covered topics such as quantitative deposition and genetic relationships with other fat depots. The relationship between leanness and higher proportions of INTMF fat in pigs was not observed in human studies and was not corroborated by other pig studies. In humans, changes in muscle mass, strength and quality are associated with INTMF accretion with aging. Gene expression profiling and intrinsic methylation differences in pigs demonstrated that INTMF and VAT are primarily associated with inflammatory and immune processes. It seems that in the pig and humans, INTMF and VAT share a similar pattern of distribution and a similar association of components dictating insulin sensitivity. Studies on intramuscular (IM) adipocyte development in meat animals were reviewed. Gene expression analysis and genetic analysis have identified candidate genes involved in IM adipocyte development. Intramuscular (IM) adipocyte development in human muscle is only seen during aging and some pathological circumstance. Several genetic links between human and meat animal adipogenesis have been identified. In pigs, the Lipin1 and Lipin 2 gene have strong genetic effects on IM accumulation. Lipin1 deficiency results in immature adipocyte development in human lipodystrophy. In humans, overexpression of Perilipin 2 (PLIN2) facilitates intramyocellular lipid accretion whereas in pigs PLIN2 gene expression is associated with IM deposition. Lipins and perilipins may influence intramuscular lipid regardless of species.

Indexed as

adipocytesadipose depot physiologydevelopmentgenetic markersgrowthintermuscular adipose tissueintramuscular adipose tissuemetabolismregulation

Identifiers

PMID26317048
PMCPMC4550684
OpenAlexW2028166871

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.