Evidence map›Paper›PMID 26317042›Full record

ArticleTremor and other hyperkinetic movements (New York, N.Y.)2015

Orthostatic Tremor: A Spectrum of Fast and Slow Frequencies or Distinct Entities?

Heather B Rigby, Matthew H Rigby, John N Caviness

Abstract read
In one paragraph

Article in Tremor and other hyperkinetic movements (New York, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Slow Orthostatic Tremor: Review of the Current Evidence.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019
    Pooled it
  3. Article
  4. Article
  5. Electrophysiological Characterization of aMovement disorders clinical practice · 2023
    Article
  6. Myoclonus and other jerky movement disorders.Clinical neurophysiology practice · 2022
    Review
  7. Video electroencephalogram combined with electromyography in the diagnosis of hyperkinetic movement disorders with an unknown cause.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Observational
  8. Article
  9. Article
  10. Tremor Syndromes: An Updated Review.Frontiers in neurology · 2021
    Review
  11. Article
  12. Article
  13. Slow Orthostatic Tremor and the Case for Routine Electrophysiological Evaluation of All Tremors.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019
    Article
  14. Article
  15. Orthostatic Tremor: Pathophysiology Guiding Treatment.Current treatment options in neurology · 2018
    Review
  16. A Rare Presentation of Orthostatic Tremor as Abdominal Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2018
    Article
  17. Review
  18. Article
  19. Orthostatic tremor: current challenges and future prospects.Degenerative neurological and neuromuscular disease · 2016
    Review
  20. Orthostatic Tremor: An Update on a Rare Entity.Tremor and other hyperkinetic movements (New York, N.Y.) · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Heather B RigbyDepartment of Neurology, Movement Disorders Center, Mayo Clinic, Scottsdale, AZ, USA ; Division of Neurology, Dalhousie University, Halifax, NS, Canada.
Matthew H RigbyDepartment of Surgery, Dalhousie University, Halifax, NS, Canada.
John N CavinessDepartment of Neurology, Movement Disorders Center, Mayo Clinic, Scottsdale, AZ, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOrthostatic tremor (OT) is defined by the presence of a high-frequency (13-18 Hz) tremor of the legs upon standing associated with a feeling of unsteadiness. However, some patients have discharge frequencies of <13 Hz, so-called "slow OT". The aim of this study was to characterize patients with unsteadiness upon standing found to have <13 Hz tremor discharges on neurophysiologic testing.

methodsA retrospective review was performed on all subjects with a diagnosis of OT who were referred to the Mayo Clinic, Scottsdale, AZ, between 1999 and 2013 for confirmation using neurophysiology.

resultsFourteen of 28 subjects (50%) had OT discharges of <13 Hz, of whom eight had frequencies of <10 Hz and six had frequencies of 10-13 Hz. Lower frequency discharges tended to have a broader spectral peak, greater variability in discharge duration, and lower inter-muscular coherence. Subjects with <13 Hz OT had shorter mean disease duration at time of neurophysiology testing (2.00 years in <10 Hz group, 7.96 years 10-13 Hz group, and 11.43 years >13 Hz; p = 0.002). The proportion of subjects who experienced gait unsteadiness (85.7% vs. 66.6% vs. 21.4%; p = 0.016), falls (37.5% vs. 50% vs. 0%; p = 0.010), and had abnormal gait on examination (71.4% vs. 66.0% vs. 14.3%; p = 0.017) was greater in those with low and intermediate frequencies. DISCUSSION: Slow tremor electromyography frequencies (<13 Hz) may characterize a substantial proportion of patients labeled as OT. These subjects may have greater gait involvement and higher likelihood of falls leading to earlier presentation to subspecialty care.

Indexed as

neurophysiologyOrthostatic tremor

Identifiers

PMID26317042
PMCPMC4548762

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.