Evidence map›Paper›PMID 26317039›Full record

ReviewJournal of biomarkers2015

Current Challenges in Volatile Organic Compounds Analysis as Potential Biomarkers of Cancer.

Kamila Schmidt, Ian Podmore

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of biomarkers, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04266990 (Investigation of Behaviour by Dogs Prior to Human Epileptic Seizures and Potential Underlying Mechanisms. Part III), which is not on this map. Cited by 68 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 6 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04266990 naterminatednot on this mapstarted 2020, after this paper: background citation

Investigation of Behaviour by Dogs Prior to Human Epileptic Seizures and Potential Underlying Mechanisms. Part III: Olfactive Discriminative Ability of Dogs When Confronted With Seizure and Non-seizure Samples Part IV: Identification of Potential Biomarkers for Epilepsy in Human Sweat.

TypeinterventionalSponsorUniversity Hospital, GhentRan2020 to 2020Enrolled31ConditionsEpilepsyArmsPlanned Sweat collection, Spontaneous Sweat collection, Healthy volunteers sweat collection
3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 6 syntheses or guidelines pooled it, 199 citations in OpenAlex.

  1. Pooled it
  2. Prostate cancer detection: a systematic review of urinary biosensors.Prostate cancer and prostatic diseases · 2022
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kamila SchmidtBiomedical Science Research Centre, School of Environment and Life Sciences, University of Salford, Manchester M5 4WT, UK.
Ian PodmoreBiomedical Science Research Centre, School of Environment and Life Sciences, University of Salford, Manchester M5 4WT, UK.
University of Salford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An early diagnosis and appropriate treatment are crucial in reducing mortality among people suffering from cancer. There is a lack of characteristic early clinical symptoms in most forms of cancer, which highlights the importance of investigating new methods for its early detection. One of the most promising methods is the analysis of volatile organic compounds (VOCs). VOCs are a diverse group of carbon-based chemicals that are present in exhaled breath and biofluids and may be collected from the headspace of these matrices. Different patterns of VOCs have been correlated with various diseases, cancer among them. Studies have also shown that cancer cells in vitro produce or consume specific VOCs that can serve as potential biomarkers that differentiate them from noncancerous cells. This review identifies the current challenges in the investigation of VOCs as potential cancer biomarkers, by the critical evaluation of available matrices for the in vivo and in vitro approaches in this field and by comparison of the main extraction and detection techniques that have been applied to date in this area of study. It also summarises complementary in vivo, ex vivo, and in vitro studies conducted to date in order to try to identify volatile biomarkers of cancer.

Identifiers

PMID26317039
PMCPMC4437398
OpenAlexW2005457708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.