Evidence map›Paper›PMID 26316894›Full record

ArticleCellular and molecular bioengineering

To Target or Not to Target: Active vs. Passive Tumor Homing of Filamentous Nanoparticles Based on

Sourabh Shukla, Nicholas A DiFranco, Amy M Wen, Ulrich Commandeur, Nicole F Steinmetz

Open access · hybridAbstract read
In one paragraph

Article in Cellular and molecular bioengineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 40 citations in OpenAlex.

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  10. Physical, chemical, and synthetic virology: Reprogramming viruses as controllable nanodevices.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Sourabh ShuklaDepartment of Biomedical Engineering, Case Western Reserve University Schools of Medicine and Engineering, Cleveland, OH 44106 USA.
Nicholas A DiFrancoDepartment of Biomedical Engineering, Case Western Reserve University Schools of Medicine and Engineering, Cleveland, OH 44106 USA.
Amy M WenDepartment of Biomedical Engineering, Case Western Reserve University Schools of Medicine and Engineering, Cleveland, OH 44106 USA.
Ulrich CommandeurInstitute for Molecular Biotechnology, RWTH Aachen University, Worringer Weg 1, 52074 Aachen, Germany.
Nicole F SteinmetzDepartment of Biomedical Engineering, Case Western Reserve University Schools of Medicine and Engineering, Cleveland, OH 44106 USA ; Department of Macromolecular Science and Engineering, Case Western Reserve University Schools of Medicine and Engineering, Cleveland, OH 44106 USA ; Department of Radiology, Case Western Reserve University Schools of Medicine and Engineering, Cleveland, OH 44106 USA ; Department of Materials Science and Engineering, Case Western Reserve University Schools of Medicine and Engineering, Cleveland, OH 44106 USA.
University School · USCase Western Reserve University · USRWTH Aachen University · DE

Funding

Cardiovascular Research Training Program (CRTP)T32HL105338 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JAIN, MUKESH KUMAR · 2010 to 2014
$1.8M
NHLBI NIH HHS T32 HL105338
6 · The paper itself

Abstract

Nanoparticles are promising platforms for the diagnosis and treatment of cancer. Diverse classes and shapes of materials have been investigated to establish design principles that achieve the effective partitioning of medical cargos between tumors and healthy tissues. Molecular targeting strategies combined with specific nanoparticle shapes confer tissue-specificity on the carriers, allowing the cell-specific delivery of cargos. We recently developed a filamentous platform technology in which the plant virus

Indexed as

BiodistributionCancerIntegrinsNanoparticle shapeTumor targeting

Identifiers

PMID26316894
PMCPMC4540758
OpenAlexW2069564782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.