SynthesisSchizophrenia bulletin2016
Meta-analysis of Positive and Negative Symptoms Reveals Schizophrenia Modifier Genes.
Synthesis in Schizophrenia bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder.Epigenomics · 2018Pooled it
- Beyond vertebrates:Frontiers in psychiatry · 2025Review
- Rare Copy Number Variation in Schizophrenia and Implications for Treatment.Schizophrenia bulletin · 2023Article
- The Effect of Clozapine and Novel Glutamate Modulator JNJ-46356479 on Nitrosative Stress in a Postnatal Murine Ketamine Model of Schizophrenia.International journal of molecular sciences · 2023Article
- Perceptual inference, accuracy, and precision in temporal reproduction in schizophrenia.Schizophrenia research. Cognition · 2022Article
- Association of g-quadruplex variants with schizophrenia symptoms.Schizophrenia research · 2022Article
- Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders.Biological psychiatry · 2022Article
- Developments in Biological Mechanisms and Treatments for Negative Symptoms and Cognitive Dysfunction of Schizophrenia.Neuroscience bulletin · 2021Review
- The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study.Translational psychiatry · 2021Article
- Evidence of an interaction betweenEuropean psychiatry : the journal of the Association of European Psychiatrists · 2021Article
- A Bioecosystem Theory of Negative Symptoms in Schizophrenia.Frontiers in psychiatry · 2021Article
- Exploring the neuropsychiatric spectrum using high-content functional analysis of single-cell signaling networks.Molecular psychiatry · 2020Article
- Current challenges and possible future developments in personalized psychiatry with an emphasis on psychotic disorders.Heliyon · 2020Review
- Polygenic Risk Scores for Subtyping of Schizophrenia.Schizophrenia research and treatment · 2020Article
- Schizophrenia, Not a Psychotic Disorder: Bleuler Revisited.Frontiers in psychiatry · 2019Review
- Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps.Genes, brain, and behavior · 2018Review
- Genetic loci associated with an earlier age at onset in multiplex schizophrenia.Scientific reports · 2017Article
- Schizophrenia genetics comes to translation.NPJ schizophrenia · 2017Article
- Cross-Disorder Psychiatric Genomics.Current behavioral neuroscience reports · 2016Article
- Parsing psychosis subtypes through investigations of rare genetic variants.EBioMedicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
backgroundEvidence suggests that genetic factors may influence both schizophrenia (Scz) and its clinical presentation. In recent years, genome-wide association studies (GWAS) have demonstrated considerable success in identifying risk loci. Detection of "modifier loci" has the potential to further elucidate underlying disease processes.
methodsWe performed GWAS of empirically derived positive and negative symptom scales in Irish cases from multiply affected pedigrees and a larger, independent case-control sample, subsequently combining these into a large Irish meta-analysis. In addition to single-SNP associations, we considered gene-based and pathway analyses to better capture convergent genetic effects, and to facilitate biological interpretation of these findings. Replication and testing of aggregate genetic effects was conducted using an independent European-American sample.
resultsThough no single marker met the genome-wide significance threshold, genes and ontologies/pathways were significantly associated with negative and positive symptoms; notably, NKAIN2 and NRG1, respectively. We observed limited overlap in ontologies/pathways associated with different symptom profiles, with immune-related categories over-represented for negative symptoms, and addiction-related categories for positive symptoms. Replication analyses suggested that genes associated with clinical presentation are generalizable to non-Irish samples.
conclusionsThese findings strongly support the hypothesis that modifier loci contribute to the etiology of distinct Scz symptom profiles. The finding that previously implicated "risk loci" actually influence particular symptom dimensions has the potential to better delineate the roles of these genes in Scz etiology. Furthermore, the over-representation of distinct gene ontologies/pathways across symptom profiles suggests that the clinical heterogeneity of Scz is due in part to complex and diverse genetic factors.
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