ArticleJournal of applied physiology (Bethesda, Md. : 1985)2015
Assessment of regional ventilation and deformation using 4D-CT imaging for healthy human lungs during tidal breathing.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
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- Pulmonary Biomechanics in COPD: Imaging Techniques and Clinical Applications.Journal of biomechanical engineering · 2025Review
- Experimental Full-volume Airway Approximation for Assessing Breath-dependent Regional Aerosol Deposition.Device · 2024Article
- A Novel Method for 3D Lung Tumor Reconstruction Using Generative Models.Diagnostics (Basel, Switzerland) · 2024Article
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- Quantitative analyzes of the variability in airways via four-dimensional dynamic ventilation CT in patients with chronic obstructive pulmonary disease: correlation with spirometry data and severity of airflow limitation.Journal of thoracic disease · 2023Article
- Quantitative Imaging Metrics for the Assessment of Pulmonary Pathophysiology: An Official American Thoracic Society and Fleischner Society Joint Workshop Report.Annals of the American Thoracic Society · 2023Article
- Functional imaging for assessing regional lung ventilation in preclinical and clinical research.Frontiers in medicine · 2023Review
- Innovations in thoracic imaging: CT, radiomics, AI and x-ray velocimetry.Respirology (Carlton, Vic.) · 2022Review
- Towards a multi-scale computer modeling workflow for simulation of pulmonary ventilation in advanced COVID-19.Computers in biology and medicine · 2022Article
- Lung tissue biomechanics imaged with synchrotron phase contrast microtomography in live rats.Scientific reports · 2022Article
- The difference in postoperative pulmonary functional change between upper and lower thoracoscopic lobectomy.Interactive cardiovascular and thoracic surgery · 2022Article
- CT-based lung motion differences in patients with usual interstitial pneumonia and nonspecific interstitial pneumonia.Frontiers in physiology · 2022Article
- Latent traits of lung tissue patterns in former smokers derived by dual channel deep learning in computed tomography images.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
This study aims to assess regional ventilation, nonlinearity, and hysteresis of human lungs during dynamic breathing via image registration of four-dimensional computed tomography (4D-CT) scans. Six healthy adult humans were studied by spiral multidetector-row CT during controlled tidal breathing as well as during total lung capacity and functional residual capacity breath holds. Static images were utilized to contrast static vs. dynamic (deep vs. tidal) breathing. A rolling-seal piston system was employed to maintain consistent tidal breathing during 4D-CT spiral image acquisition, providing required between-breath consistency for physiologically meaningful reconstructed respiratory motion. Registration-derived variables including local air volume and anisotropic deformation index (ADI, an indicator of preferential deformation in response to local force) were employed to assess regional ventilation and lung deformation. Lobar distributions of air volume change during tidal breathing were correlated with those of deep breathing (R(2) ≈ 0.84). Small discrepancies between tidal and deep breathing were shown to be likely due to different distributions of air volume change in the left and the right lungs. We also demonstrated an asymmetric characteristic of flow rate between inhalation and exhalation. With ADI, we were able to quantify nonlinearity and hysteresis of lung deformation that can only be captured in dynamic images. Nonlinearity quantified by ADI is greater during inhalation, and it is stronger in the lower lobes (P < 0.05). Lung hysteresis estimated by the difference of ADI between inhalation and exhalation is more significant in the right lungs than that in the left lungs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.