ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2016
Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02896452 (Astronaut Vision Issues and One Carbon Metabolism), which is not on this map. Cited by 37 papers.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Astronaut Vision Issues and One Carbon Metabolism: Expanded Polymorphism Evaluation and Evaluation in a Potential Analog Population
Who cites it
37 citing papers in PubMed, 83 citations in OpenAlex.
- An eye on long-duration spaceflight: Controversies, countermeasures and challenges.Experimental physiology · 2026Review
- Spaceflight-associated neuro-ocular syndrome (SANS): expert consensus on diagnosis and management.Eye (London, England) · 2026Review
- In search of a mouse model of Spaceflight Associated Neuro-ocular Syndrome using one-carbon genetics.Scientific reports · 2026Article
- Ocular health in outer space and beyond gravity: A minireview.World journal of clinical cases · 2026Review
- Precision Medicine in Astronauts: Principles and Targets in Molecular Assessment.Methods in molecular biology (Clifton, N.J.) · 2026Review
- Predicting Spaceflight-Associated Neuro-Ocular Syndrome in International Space Station Astronauts.JAMA ophthalmology · 2025Article
- Spaceflight Associated Neuro-ocular Syndrome (SANS) and its countermeasures.Progress in retinal and eye research · 2025Review
- Spatial and Temporal Changes in Choroid Morphology Associated With Long-Duration Spaceflight.Investigative ophthalmology & visual science · 2025Article
- A multifactorial, evidence-based analysis of pathophysiology in Spaceflight Associated Neuro-Ocular Syndrome (SANS).Eye (London, England) · 2025Review
- Protective alleles and precision healthcare in crewed spaceflight.Nature communications · 2024Review
- Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology.Communications medicine · 2024Article
- Astronaut omics and the impact of space on the human body at scale.Nature communications · 2024Review
- Mitochondrial dysfunction in Spaceflight Associated Neuro-Ocular Syndrome (SANS): a molecular hypothesis in pathogenesis.Eye (London, England) · 2024Article
- Ocular oxidative changes and antioxidant therapy during spaceflight.Eye (London, England) · 2024Article
- Spaceflight associated neuro-ocular syndrome (SANS): an update on potential microgravity-based pathophysiology and mitigation development.Eye (London, England) · 2023Review
- Artificial Intelligence Frameworks to Detect and Investigate the Pathophysiology of Spaceflight Associated Neuro-Ocular Syndrome (SANS).Brain sciences · 2023Review
- Spaceflight associated neuro-ocular syndrome: proposed pathogenesis, terrestrial analogues, and emerging countermeasures.The British journal of ophthalmology · 2023Review
- More than a Feeling: Dermatological Changes Impacted by Spaceflight.Research square · 2023Article
- Optic disc edema during strict 6° head-down tilt bed rest is related to one-carbon metabolism pathway genetics and optic cup volume.Frontiers in ophthalmology · 2023Article
- Rare diseases and space health: optimizing synergies from scientific questions to care.NPJ microgravity · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 9 institutions in 3 countries.
Sara R Zwart*Division of Space Life Sciences, Universities Space Research Association, Houston, Texas, USA; Food Science and Human Nutrition, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, USA; Nutrition Research Institute, University of North Carolina at Kannapolis, Kannapolis, North Carolina, USA; Coastal Eye Associates, Webster, Texas, USA; Cooper Landing, Alaska, USA; Metabolon, Incorporated, Durham, North Carolina, USA; Department of Clinical Science, University of Bergen, Bergen, Norway; **Department of Nutrition and Food Science, Nutritional Physiology, University of Bonn, Bonn, Germany; and Biomedical Research and Environmental Sciences Division, National Aeronautics and Space Administration Johnson Space Center, Houston, Texas, USA.
Jesse F Gregory*Division of Space Life Sciences, Universities Space Research Association, Houston, Texas, USA; Food Science and Human Nutrition, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, USA; Nutrition Research Institute, University of North Carolina at Kannapolis, Kannapolis, North Carolina, USA; Coastal Eye Associates, Webster, Texas, USA; Cooper Landing, Alaska, USA; Metabolon, Incorporated, Durham, North Carolina, USA; Department of Clinical Science, University of Bergen, Bergen, Norway; **Department of Nutrition and Food Science, Nutritional Physiology, University of Bonn, Bonn, Germany; and Biomedical Research and Environmental Sciences Division, National Aeronautics and Space Administration Johnson Space Center, Houston, Texas, USA.
Steven H Zeisel*Division of Space Life Sciences, Universities Space Research Association, Houston, Texas, USA; Food Science and Human Nutrition, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, USA; Nutrition Research Institute, University of North Carolina at Kannapolis, Kannapolis, North Carolina, USA; Coastal Eye Associates, Webster, Texas, USA; Cooper Landing, Alaska, USA; Metabolon, Incorporated, Durham, North Carolina, USA; Department of Clinical Science, University of Bergen, Bergen, Norway; **Department of Nutrition and Food Science, Nutritional Physiology, University of Bonn, Bonn, Germany; and Biomedical Research and Environmental Sciences Division, National Aeronautics and Space Administration Johnson Space Center, Houston, Texas, USA.
Charles R Gibson*Division of Space Life Sciences, Universities Space Research Association, Houston, Texas, USA; Food Science and Human Nutrition, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, USA; Nutrition Research Institute, University of North Carolina at Kannapolis, Kannapolis, North Carolina, USA; Coastal Eye Associates, Webster, Texas, USA; Cooper Landing, Alaska, USA; Metabolon, Incorporated, Durham, North Carolina, USA; Department of Clinical Science, University of Bergen, Bergen, Norway; **Department of Nutrition and Food Science, Nutritional Physiology, University of Bonn, Bonn, Germany; and Biomedical Research and Environmental Sciences Division, National Aeronautics and Space Administration Johnson Space Center, Houston, Texas, USA.
Thomas H Mader*Division of Space Life Sciences, Universities Space Research Association, Houston, Texas, USA; Food Science and Human Nutrition, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, USA; Nutrition Research Institute, University of North Carolina at Kannapolis, Kannapolis, North Carolina, USA; Coastal Eye Associates, Webster, Texas, USA; Cooper Landing, Alaska, USA; Metabolon, Incorporated, Durham, North Carolina, USA; Department of Clinical Science, University of Bergen, Bergen, Norway; **Department of Nutrition and Food Science, Nutritional Physiology, University of Bonn, Bonn, Germany; and Biomedical Research and Environmental Sciences Division, National Aeronautics and Space Administration Johnson Space Center, Houston, Texas, USA scott.m.smith@nasa.gov.
Jason M Kinchen*Division of Space Life Sciences, Universities Space Research Association, Houston, Texas, USA; Food Science and Human Nutrition, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, USA; Nutrition Research Institute, University of North Carolina at Kannapolis, Kannapolis, North Carolina, USA; Coastal Eye Associates, Webster, Texas, USA; Cooper Landing, Alaska, USA; Metabolon, Incorporated, Durham, North Carolina, USA; Department of Clinical Science, University of Bergen, Bergen, Norway; **Department of Nutrition and Food Science, Nutritional Physiology, University of Bonn, Bonn, Germany; and Biomedical Research and Environmental Sciences Division, National Aeronautics and Space Administration Johnson Space Center, Houston, Texas, USA.
Per M Ueland*Division of Space Life Sciences, Universities Space Research Association, Houston, Texas, USA; Food Science and Human Nutrition, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, USA; Nutrition Research Institute, University of North Carolina at Kannapolis, Kannapolis, North Carolina, USA; Coastal Eye Associates, Webster, Texas, USA; Cooper Landing, Alaska, USA; Metabolon, Incorporated, Durham, North Carolina, USA; Department of Clinical Science, University of Bergen, Bergen, Norway; **Department of Nutrition and Food Science, Nutritional Physiology, University of Bonn, Bonn, Germany; and Biomedical Research and Environmental Sciences Division, National Aeronautics and Space Administration Johnson Space Center, Houston, Texas, USA.
Robert Ploutz-Snyder*Division of Space Life Sciences, Universities Space Research Association, Houston, Texas, USA; Food Science and Human Nutrition, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, USA; Nutrition Research Institute, University of North Carolina at Kannapolis, Kannapolis, North Carolina, USA; Coastal Eye Associates, Webster, Texas, USA; Cooper Landing, Alaska, USA; Metabolon, Incorporated, Durham, North Carolina, USA; Department of Clinical Science, University of Bergen, Bergen, Norway; **Department of Nutrition and Food Science, Nutritional Physiology, University of Bonn, Bonn, Germany; and Biomedical Research and Environmental Sciences Division, National Aeronautics and Space Administration Johnson Space Center, Houston, Texas, USA.
Martina A Heer*Division of Space Life Sciences, Universities Space Research Association, Houston, Texas, USA; Food Science and Human Nutrition, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, USA; Nutrition Research Institute, University of North Carolina at Kannapolis, Kannapolis, North Carolina, USA; Coastal Eye Associates, Webster, Texas, USA; Cooper Landing, Alaska, USA; Metabolon, Incorporated, Durham, North Carolina, USA; Department of Clinical Science, University of Bergen, Bergen, Norway; **Department of Nutrition and Food Science, Nutritional Physiology, University of Bonn, Bonn, Germany; and Biomedical Research and Environmental Sciences Division, National Aeronautics and Space Administration Johnson Space Center, Houston, Texas, USA.
Scott M Smith*Division of Space Life Sciences, Universities Space Research Association, Houston, Texas, USA; Food Science and Human Nutrition, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, USA; Nutrition Research Institute, University of North Carolina at Kannapolis, Kannapolis, North Carolina, USA; Coastal Eye Associates, Webster, Texas, USA; Cooper Landing, Alaska, USA; Metabolon, Incorporated, Durham, North Carolina, USA; Department of Clinical Science, University of Bergen, Bergen, Norway; **Department of Nutrition and Food Science, Nutritional Physiology, University of Bonn, Bonn, Germany; and Biomedical Research and Environmental Sciences Division, National Aeronautics and Space Administration Johnson Space Center, Houston, Texas, USA scott.m.smith@nasa.gov.
Universities Space Research Association · USCooper Institute · USDavid H. Murdock Research Institute · USHouston Eye Associates · USJohnson Space Center · USMetabolon (United States) · USUniversity of Bergen · NOUniversity of Bonn · DEUniversity of Florida · US
Funding
Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MUNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6MNCATS NIH HHS UL1 TR001427NIDDK NIH HHS DK56350NIDDK NIH HHS P30 DK056350NIEHS NIH HHS P30 ES010126
Abstract
Ophthalmic changes have occurred in a subset of astronauts on International Space Station missions. Visual deterioration is considered the greatest human health risk of spaceflight. Affected astronauts exhibit higher concentrations of 1-carbon metabolites (e.g., homocysteine) before flight. We hypothesized that genetic variations in 1-carbon metabolism genes contribute to susceptibility to ophthalmic changes in astronauts. We investigated 5 polymorphisms in the methionine synthase reductase (MTRR), methylenetetrahydrofolate reductase (MTHFR), serine hydroxymethyltransferase (SHMT), and cystathionine β-synthase (CBS) genes and their association with ophthalmic changes after flight in 49 astronauts. The number of G alleles of MTRR 66 and C alleles of SHMT1 1420 both contributed to the odds of visual disturbances. Preflight dehydroepiandrosterone was positively associated with cotton wool spots, and serum testosterone response during flight was associated with refractive change. Block regression showed that B-vitamin status and genetics were significant predictors of many of the ophthalmic outcomes that we observed. In one example, genetics trended toward improving (P = 0.10) and B-vitamin status significantly improved (P < 0.001) the predictive model for refractive change after flight. We document an association between MTRR 66 and SHMT1 1420 polymorphisms and spaceflight-induced vision changes. This line of research could lead to therapeutic options for both space travelers and terrestrial patients.
Indexed as
Space FlightVisual PerceptionAdultAgedAndrogensFemaleFerredoxin-NADP ReductaseGenotypeGlycine HydroxymethyltransferaseHumansMaleMiddle AgedPolymorphism, GeneticVitaminsAndrogensFerredoxin-NADP ReductaseGlycine Hydroxymethyltransferasemethionine synthase reductaseSHMT protein, humanVitamins
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT02896452ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.