Evidence map›Paper›PMID 26316245›Full record

ReviewEndocrinology and metabolism clinics of North America2015

The Effect of Menopausal Hormone Therapies on Breast Cancer: Avoiding the Risk.

Valerie A Flores, Hugh S Taylor

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Endocrinology and metabolism clinics of North America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Valerie A FloresWomen and Infants Hospital, Warren Alpert Medical School of Brown University, 222 Richmond Street, Providence, RI 02903, USA.
Hugh S TaylorDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address: hugh.taylor@yale.edu.
Brown University · USYale University · US

Funding

The Yale WRHR Career Development CenterK12HD047018 · NICHD · YALE UNIVERSITY · PI Hugh Smith Taylor · 2004 to 2026
$7.8M
HOX Gene Expression by Endocrine Disrupting ChemicalsR01ES010610 · NIEHS · YALE UNIVERSITY · PI TAYLOR, HUGH SMITH · 2001 to 2011
$2.9M
Hox Gene Expression in Human EndometriumR01HD036887 · NICHD · YALE UNIVERSITY · PI TAYLOR, HUGH S · 2003 to 2007
$1.4M
NICHD NIH HHS K12 HD047018NICHD NIH HHS R01 HD036887NIEHS NIH HHS R01 ES010610
6 · The paper itself

Abstract

Estrogen and P treatment results in greater risk of breast cancer than placebo. Treatment with estrogen alone does not increase the risk of breast cancer, may be used by women who have had a hysterectomy, and may even result in a decreased risk of breast cancer. Continued research seeks to improve the understanding of the interplay between estrogen and progestogens that predispose to adverse effects on breast tissue. Caution over this hypothesized benefit is warranted until it is substantiated by data on the incidence of breast cancer in tissue selective estrogen complex users.

Indexed as

MenopauseBreast NeoplasmsEstrogen Replacement TherapyFemaleHumansRisk FactorsBreast cancerEstrogensHormone therapyMenopauseProgestogen

Identifiers

PMID26316245
PMCPMC4555991
OpenAlexW786312503

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.