Evidence map›Paper›PMID 26316239›Full record

ReviewEndocrinology and metabolism clinics of North America2015

Menopausal Symptoms and Their Management.

Nanette Santoro, C Neill Epperson, Sarah B Mathews

4 registry-linked trialsAbstract readReview
In one paragraph

Review in Endocrinology and metabolism clinics of North America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 235 papers, 24 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
235citing papers in PubMed, 24 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05282277 phase4recruitingnot on this mapstarted 2022, after this paper: background citation

Examining the Effects of Estradiol on Neural and Molecular Response to Rewards in Perimenopausal-Onset Anhedonia and Psychosis

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2022 to 2026Enrolled103ConditionsDepression, Psychosis, AnhedoniaArmsTransdermal Estradiol, Micronized Progesterone, Matching Placebo Patch, Raclopride C11
NCT05293860 nacompletednot on this mapstarted 2022, after this paper: background citation

Effects of Connective Tissue Manipulation on Menopausal Symptoms

TypeinterventionalSponsorHacettepe UniversityRan2022 to 2023Enrolled52ConditionsMenopause SyndromeArmsConnective tissue manipulation, Superficial massage with the head of the therapeutic ultrasound device
NCT05677698 nacompletednot on this mapstarted 2022, after this paper: background citation

Menoupausal Symptoms and Aromatherapy

TypeinterventionalSponsorKTO Karatay UniversityRan2022 to 2023Enrolled90ConditionsAromatherapyArmsLemon oil, peppermint oil, Almond oil
NCT05764031 nacompletednot on this mapstarted 2020, after this paper: background citation

Comparative Effects of Clinical Pilates Training and Aerobic Exercise on Menopausal Symptoms, Quality of Life, Sleep and Depression

TypeinterventionalSponsorHasan Kalyoncu UniversityRan2020 to 2022Enrolled30ConditionsMenopauseArmsClinical pilates exercise, Aerobic exercise
3 · Its place in the literature

Who cites it

235 citing papers in PubMed, 24 syntheses or guidelines pooled it, 609 citations in OpenAlex.

  1. Factors Associated With Menopause Symptoms: A Systematic Review and Meta-Analysis.BJOG : an international journal of obstetrics and gynaecology · 2026
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  4. High-intensity resistance and impact exercise in menopausal women: a systematic review of intervention reporting quality and training content.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
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  7. FIGO best practice recommendations for the mental health of women at menopausal age.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Guideline
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  18. Aromatase enzyme: Paving the way for exploring aromatization for cardio-renal protection.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023
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175 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Nanette SantoroDepartment of Obstetrics & Gynecology, University of Colorado School of Medicine, 12631 East 17th Avenue, AO1, Room 4010, Aurora, CO 80045, USA. Electronic address: Nanette.Santoro@ucdenver.edu.
C Neill EppersonDepartment of Psychiatry Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, 3rd Floor, Philadelphia, PA 19104-3309, USA.
Sarah B MathewsDepartment of Psychiatry Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, 3rd Floor, Philadelphia, PA 19104-3309, USA.
University of Pennsylvania · USUniversity of Colorado Denver · US

Funding

Prepubertal Stress, Windows of Risk & Sex Bias for Affective DisturbanceP50MH099910 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BALE, TRACY L · 2012 to 2017
$6.5M
Reversing Impact of Childhood Adversity on MDD & Cognitive Decline in MenopauseR01AG048839 · NIA · UNIVERSITY OF PENNSYLVANIA · PI EPPERSON, C. NEILL · 2014 to 2015
$630k
NIA NIH HHS R01 AG048839NIMH NIH HHS P50 MH099910
6 · The paper itself

Abstract

The menopause transition is associated with various symptoms, which can interact to produce morbidity. Vasomotor symptoms are the most commonly reported, but vaginal dryness/dyspareunia, sleep difficulties and adverse mood changes have all been shown to worsen as women approach menopause. For postmenopausal women changes in cognition are more likely to be related to aging and not to hormones. This article reviews the symptoms of hot flashes (vasomotor symptoms), vaginal dryness/dyspareunia, adverse mood, poor sleep/insomnia, and cognitive complaints, describing their epidemiology, diagnosis, and treatment. This article thus reviews the epidemiology, pathophysiology, diagnosis, and treatment of these common menopausal symptoms.

Indexed as

AgingCognitionDepressionEstrogen Replacement TherapyFemaleHot FlashesHumansMenopauseCognitive impairmentDepressionDyspareuniaInsomniaMenopausePerimenopauseVaginal drynessVasomotor symptoms

Identifiers

PMID26316239
PMCPMC4890704
OpenAlexW1850592943

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.