ArticleScientific reports2015
Stability analysis of a model gene network links aging, stress resistance, and negligible senescence.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Multi-Omics Signatures of Organ Clocks in Biological Aging and Disease: A Conceptual Framework for Organ-Specific Aging Clocks.Aging cell · 2026Review
- Computational Systems Biology Approaches to Cellular Aging - Integrating Network Maps and Dynamical Models.Quantitative biology (Beijing, China) · 2025Article
- Transcriptional drift in aging cells: A global decontroller.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Transcriptional drift in aging cells: A global de-controller.bioRxiv : the preprint server for biology · 2023Article
- Article
- Unsupervised learning of aging principles from longitudinal data.Nature communications · 2022Article
- Stability of Gene Regulatory Networks Modeled by Generalized Proportional Caputo Fractional Differential Equations.Entropy (Basel, Switzerland) · 2022Article
- Article
- Unique age-related transcriptional signature in the nervous system of the long-lived red sea urchin Mesocentrotus franciscanus.Scientific reports · 2020Article
- A universal transcriptomic signature of age reveals the temporal scaling of Caenorhabditis elegans aging trajectories.Scientific reports · 2019Article
- Fountain of youth for squamous cell carcinomas? On the epigenetic age of non-small cell lung cancer and corresponding tumor-free lung tissues.International journal of cancer · 2018Article
- Hacking Aging: A Strategy to Use Big Data From Medical Studies to Extend Human Life.Frontiers in genetics · 2018Article
- Intercellular competition and the inevitability of multicellular aging.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Genome Stability Maintenance in Naked Mole-Rat.Acta naturaeArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several animal species are considered to exhibit what is called negligible senescence, i.e. they do not show signs of functional decline or any increase of mortality with age. Recent studies in naked mole rat and long-lived sea urchins showed that these species do not alter their gene-expression profiles with age as much as other organisms do. This is consistent with exceptional endurance of naked mole rat tissues to various genotoxic stresses. We conjectured, therefore, that the lifelong transcriptional stability of an organism may be a key determinant of longevity. We analyzed the stability of a simple genetic-network model and found that under most common circumstances, such a gene network is inherently unstable. Over a time it undergoes an exponential accumulation of gene-regulation deviations leading to death. However, should the repair systems be sufficiently effective, the gene network can stabilize so that gene damage remains constrained along with mortality of the organism. We investigate the relationship between stress-resistance and aging and suggest that the unstable regime may provide a mathematical basis for the Gompertz "law" of aging in many species. At the same time, this model accounts for the apparently age-independent mortality observed in some exceptionally long-lived animals.
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