Evidence map›Paper›PMID 26315980›Full record

Trial reportThe American journal of psychiatry2016

Baseline Striatal Functional Connectivity as a Predictor of Response to Antipsychotic Drug Treatment.

Deepak K Sarpal, Miklos Argyelan, Delbert G Robinson, Philip R Szeszko, Katherine H Karlsgodt, Majnu John, Noah Weissman, Juan A Gallego, John M Kane, Todd Lencz and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04671836 (Lorazepam Effects on Neuroimaging Measures), which is not on this map. Cited by 125 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
125citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04671836 early_phase1withdrawnnot on this mapstarted 2022, after this paper: background citation

Lorazepam Effects on Neuroimaging Measures: A Pilot Study

TypeinterventionalSponsorNorthwell HealthRan2022 to 2022Enrolled0ConditionsLorazepam, NeuroimagingArmsLorazepam 1Mg Tablet, Placebo
3 · Its place in the literature

Who cites it

125 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Heterogeneity and efficacy of antipsychotic treatment for schizophrenia with or without treatment resistance: a meta-analysis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Observational
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

65 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Deepak K SarpalFrom the Department of Psychiatry, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, N.Y.; the Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry, Hofstra North Shore-LIJ School of Medicine, Hempstead, N.Y.; and the Department of Mathematics, Hofstra University, Hempstead, N.Y.
Miklos ArgyelanFrom the Department of Psychiatry, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, N.Y.; the Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry, Hofstra North Shore-LIJ School of Medicine, Hempstead, N.Y.; and the Department of Mathematics, Hofstra University, Hempstead, N.Y.
Delbert G RobinsonFrom the Department of Psychiatry, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, N.Y.; the Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry, Hofstra North Shore-LIJ School of Medicine, Hempstead, N.Y.; and the Department of Mathematics, Hofstra University, Hempstead, N.Y.
Philip R SzeszkoFrom the Department of Psychiatry, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, N.Y.; the Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry, Hofstra North Shore-LIJ School of Medicine, Hempstead, N.Y.; and the Department of Mathematics, Hofstra University, Hempstead, N.Y.
Katherine H KarlsgodtFrom the Department of Psychiatry, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, N.Y.; the Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry, Hofstra North Shore-LIJ School of Medicine, Hempstead, N.Y.; and the Department of Mathematics, Hofstra University, Hempstead, N.Y.
Majnu JohnFrom the Department of Psychiatry, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, N.Y.; the Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry, Hofstra North Shore-LIJ School of Medicine, Hempstead, N.Y.; and the Department of Mathematics, Hofstra University, Hempstead, N.Y.
Noah WeissmanFrom the Department of Psychiatry, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, N.Y.; the Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry, Hofstra North Shore-LIJ School of Medicine, Hempstead, N.Y.; and the Department of Mathematics, Hofstra University, Hempstead, N.Y.
Juan A GallegoFrom the Department of Psychiatry, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, N.Y.; the Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry, Hofstra North Shore-LIJ School of Medicine, Hempstead, N.Y.; and the Department of Mathematics, Hofstra University, Hempstead, N.Y.
John M KaneFrom the Department of Psychiatry, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, N.Y.; the Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry, Hofstra North Shore-LIJ School of Medicine, Hempstead, N.Y.; and the Department of Mathematics, Hofstra University, Hempstead, N.Y.
Todd LenczFrom the Department of Psychiatry, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, N.Y.; the Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry, Hofstra North Shore-LIJ School of Medicine, Hempstead, N.Y.; and the Department of Mathematics, Hofstra University, Hempstead, N.Y.
Anil K MalhotraFrom the Department of Psychiatry, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, N.Y.; the Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry, Hofstra North Shore-LIJ School of Medicine, Hempstead, N.Y.; and the Department of Mathematics, Hofstra University, Hempstead, N.Y.

Funding

Striatal D2/D3 Dopamine receptor availability in first episode schizophreniaP50MH080173 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI KANE, JOHN M · 2008 to 2012
$10.4M
Trials Operation Unit (OPERATIONS CORE)P30MH090590 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI PETRIDES, GEORGIOS · 2010 to 2014
$7.9M
PREVENTING MORBIDITY IN FIRST EPISODE SCHIZOPHRENIAR01MH060004 · NIMH · LONG ISLAND JEWISH MEDICAL CENTER · PI ROBINSON, DELBERT G · 1998 to 2008
$5.2M
Diffusion Tensor Imaging in First-Episode SchizophreniaR01MH076995 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI SZESZKO, PHILIP R · 2007 to 2010
$1.2M
MicroRNAs as Biomarkers in First-episode SchizophreniaK23MH100264 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI GALLEGO, JUAN ANDRES · 2013 to 2017
$893k
NIMH NIH HHS K23 MH100264NIMH NIH HHS K23MH100264NIMH NIH HHS P30 MH090590NIMH NIH HHS P30MH090590NIMH NIH HHS P50 MH080173NIMH NIH HHS P50MH080173NIMH NIH HHS R01 MH060004NIMH NIH HHS R01MH060004NIMH NIH HHS R01 MH076995NIMH NIH HHS R01MH076995
6 · The paper itself

Abstract

objectiveClinical response to antipsychotic drug treatment is highly variable, yet prognostic biomarkers are lacking. The authors recently demonstrated that successful antipsychotic drug treatment alters resting-state functional connectivity of the striatum. The goal of the present study was to test whether intrinsic striatal connectivity patterns provide prognostic information and can serve as a potential biomarker of treatment response to antipsychotic drugs.

methodThe authors used resting-state functional MRI (fMRI) to develop a prognostic index in a discovery cohort of 41 first-episode schizophrenia patients, then tested this index in an independent cohort of 40 newly hospitalized chronic patients with acute psychosis. In the discovery cohort, patients underwent resting-state fMRI scanning at the initiation of randomized controlled treatment with a second-generation antipsychotic. Whole-brain functional connectivity maps were generated for each subject from striatal seed regions. A stringent measure of clinical response was calculated that required sustained improvement over two consecutive study visits. Clinical response was entered into a survival analysis, and Cox regression was applied to the functional connectivity data. A striatal connectivity index was created, comprising functional connections of the striatum that predicted treatment response. This striatal connectivity index was tested on a generalizability cohort of patients with psychotic disorders who were hospitalized for an acute psychotic episode.

resultsA total of 91 regions functionally connected with the striatum provided significant prognostic information. Connectivity in these regions was used to create a baseline striatal connectivity index that predicted response to antipsychotic treatment with high sensitivity and specificity in both the discovery and generalizability cohorts.

conclusionsThese results provide evidence that individual differences in striatal functional connectivity predict response to antipsychotic drug treatment in acutely psychotic patients. With further development, this has the potential to serve as a prognostic biomarker with clinical utility and to reduce the overall burden associated with psychotic illnesses.

Indexed as

AripiprazoleCorpus StriatumRisperidoneSchizophreniaAdolescentAdultAntipsychotic AgentsConnectomeFemaleHumansMagnetic Resonance ImagingMalePrognosisReproducibility of ResultsTreatment OutcomeAntipsychotic AgentsAripiprazoleRisperidone

Identifiers

PMID26315980
PMCPMC4845897

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.