SynthesisHead & face medicine2015
Does low level laser therapy relieve the pain caused by the placement of the orthodontic separators?--A meta-analysis.
Synthesis in Head & face medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Comparative efficacy of pharmaceutical (Ibuprofen) and non-pharmaceutical (photobiomodulation, and chewing gum) interventions for pain reduction after elastomeric separator placement in orthodontic patients: a randomized clinical trial.Lasers in medical science · 2024Trial
- Separation and pain perception of Elastomeric, Kesling and Kansal separators.Dental press journal of orthodontics · 2019Trial
- Trial
- Clinical study on the efficacy of LED phototherapy for pain control in an orthodontic procedure.Lasers in medical science · 2019Trial
- Effects of diode laser (980 nm) on orthodontic tooth movement and interleukin 6 levels in gingival crevicular fluid in female subjects.Lasers in medical science · 2016Trial
- Photobiomodulation in orthodontics: an overview of systematic reviews with meta-regression and evidence map.Odontology · 2026Review
- Photobiomodulation Meets Mechanotransduction: Immune-Stromal Crosstalk in Orthodontic Remodeling.Biomedicines · 2025Review
- The Effect of Low-Level Laser Therapy to Reduce Pain Caused by Orthodontic Separators: A Randomized, Double-Blind Placebo-Controlled, Split-Mouth Study.Dentistry journal · 2025Article
- Evaluation of pain experienced by orthodontic patients following elastomeric separator insertion: A cross-sectional study.Korean journal of orthodontics · 2023Article
- Efficacy of Photobiomodulation Therapy for Orthodontic Pain Control Following the Placement of Elastomeric Separators: A Randomized Clinical Trial.Journal of lasers in medical sciences · 2021Article
- The Effectiveness of Low-Level Laser Therapy in Pain Induced by Orthodontic Separator Placement: A Systematic Review.Journal of lasers in medical sciences · 2021Review
- Current advances in orthodontic pain.International journal of oral science · 2016Review
- Pain and distress induced by elastomeric and spring separators in patients undergoing orthodontic treatment.Journal of International Society of Preventive & Community DentistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePain caused by orthodontic treatment can affect patient's compliance and even force them to terminate treatments. The aim of this meta-analysis is to evaluate of the analgesic effect of low level laser therapy (LLLT) after placement of the orthodontic separators.
methodsFive databases: PubMed, Embase, Cochrane library, China Biology Medicine disc (SinoMed CBM), China National Knowledge Infrastructure (CNKI) were searched for all the appropriate studies in June, 2014. Two reviewers screened the research results under our inclusion criteria and evaluated the risk of bias independently. Then the data of the included studies was extracted for quantitative analysis by the Review Manager 5.1 software.
resultsSix studies were included in our meta-analysis finally. Comparing to the placebo group, the LLLT has good analgesic effect at 6 h, 1d, 2d, 3d after placement of separators which is of statistical significance. While at 2 h, 4d, 5d after the placement, the results tend to support LLLT, but not statistically significant.
conclusionBased on current included studies, LLLT can reduce the pain caused by the placement of separators effectively. However, because of the high heterogeneity, well designed RCTs are required in the future.
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