Evidence map›Paper›PMID 26315859›Full record

SynthesisSeminars in arthritis and rheumatism2016

Vasculitis in patients with inflammatory bowel diseases: A study of 32 patients and systematic review of the literature.

Alice Sy, Nader Khalidi, Natasha Dehghan, Lillian Barra, Simon Carette, David Cuthbertson, Gary S Hoffman, Curry L Koening, Carol A Langford, Carol McAlear and 11 more

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Seminars in arthritis and rheumatism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 3 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 3 syntheses or guidelines pooled it, 151 citations in OpenAlex.

  1. Guideline
  2. Real-World Biomarkers for Pediatric Takayasu Arteritis.International journal of molecular sciences · 2024
    Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Review
  7. Cutaneous Arteritis Complicated by Crohn's Disease.Internal medicine (Tokyo, Japan) · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 14 institutions in 2 countries.

Alice SyDivision of Rheumatology, Mount Sinai Hospital, University of Toronto, The Joseph and Wolf Lebovic Building, 60 Murray St, Ste 2-220, Toronto, Ontario, Canada M5T 3L9.
Nader KhalidiDivision of Rheumatology, McMaster University, Hamilton, Ontario, Canada.
Natasha DehghanDivision of Rheumatology, University of British Columbia, Vancouver, British Columbia, Canada.
Lillian BarraDivision of Rheumatology, St. Joseph's Health Care, London, Ontario, Canada.
Simon CaretteDivision of Rheumatology, Mount Sinai Hospital, University of Toronto, The Joseph and Wolf Lebovic Building, 60 Murray St, Ste 2-220, Toronto, Ontario, Canada M5T 3L9.
David CuthbertsonDepartment of Biostatistics, University of South Florida, Tampa, FL.
Gary S HoffmanCenter for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH.
Curry L KoeningDivision of Rheumatology, University of Utah, Salt Lake City, UT.
Carol A LangfordCenter for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH.
Carol McAlearDivision of Rheumatology, University of Pennsylvania, Philadelphia, PA.
Larry MorelandDivision of Rheumatology, University of Pittsburgh, Pittsburgh, PA.
Paul A MonachThe Vasculitis Center, Section of Rheumatology, Boston University School of Medicine, Boston, MA; Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA.
Philip SeoDivision of Rheumatology, Johns Hopkins University, Baltimore, MD.
Ulrich SpecksDivision of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN.
Antoine SreihDivision of Rheumatology, University of Pennsylvania, Philadelphia, PA.
Steven R YtterbergDivision of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN.
Gert Van AsscheDivision of Gastroenterology, University of Toronto-Inflammatory Bowel Disease Clinic, Toronto, Ontario, Canada.
Peter A MerkelDivision of Rheumatology, University of Pennsylvania, Philadelphia, PA.
Christian PagnouxDivision of Rheumatology, Mount Sinai Hospital, University of Toronto, The Joseph and Wolf Lebovic Building, 60 Murray St, Ste 2-220, Toronto, Ontario, Canada M5T 3L9. Electronic address: cpagnoux@msn.com.
Vasculitis Clinical Research Consortium (VCRC)
Canadian Vasculitis Network (CanVasc)
University of Pennsylvania · USUniversity of Toronto · CACleveland Clinic · USBoston University · USJohns Hopkins University · USMayo Clinic · USMayo Clinic in Arizona · USMcMaster University · CAMount Sinai Hospital · CASt Joseph's Health Care · CAUniversity of British Columbia · CAUniversity of Pittsburgh · USUniversity of South Florida · USUniversity of Utah · US

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
VCRC-VF FellowshipU54AR057319 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI MERKEL, PETER A · 2009 to 2020
$12.5M
VASCULITIS CLINICAL RESEARCH NETWORK (VCRN): RARE DISEASEU54RR019497 · NCRR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MERKEL, PETER A · 2003 to 2008
$6.1M
Vasculitis Outcome Measures: Development and ValidationU01AR051874 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI MERKEL, PETER A · 2005 to 2006
$386k
NCATS NIH HHS UL1 TR000439NCRR NIH HHS U54 RR019497NCRR NIH HHS U54RR019497NIAMS NIH HHS U01AR5187404NIAMS NIH HHS U54 AR057319NIAMS NIH HHS U54AR057319
6 · The paper itself

Abstract

backgroundPublished small case series suggest that inflammatory bowel disease [IBD; Crohn's disease (CD) or ulcerative colitis (UC)] and vasculitis co-occur more frequently than would be expected by chance.

objectivesTo describe this association by an analysis of a large cohort of carefully studied patients and through a systematic literature review.

methodsPatients with both IBD and vasculitis enrolled in the Vasculitis Clinical Research Consortium (VCRC) Longitudinal Studies, followed in Canadian Vasculitis research network (CanVasc) centers and/or in the University of Toronto's IBD clinic were included in this case series. A systematic literature review of patients with IBD and vasculitis involved a PubMed search through February 2014. The main characteristics of patients with Takayasu arteritis (TAK) and IBD were compared to those in patients with TAK without IBD followed in the VCRC.

resultsThe study identified 32 patients with IBD and vasculitis: 13 with large-vessel vasculitis [LVV; 12 with TAK, 1 with giant cell arteritis (GCA); 8 with CD, 5 with UC]; 8 with ANCA-associated vasculitis [AAV; 6 granulomatosis with polyangiitis (GPA), 2 with eosinophilic granulomatosis with polyangiitis (EGPA)]; 5 with isolated cutaneous vasculitis; and 6 with other vasculitides. Patients with LVV and AAV were mostly female (18/21). The diagnosis of IBD preceded that of vasculitis in 12/13 patients with LVV and 8/8 patients with AAV. The review of the literature identified 306 patients with IBD and vasculitis: 144 with LVV (133 TAK; 87 with IBD preceding LVV), 19 with AAV [14 GPA, 1 EGPA, 4 microscopic polyangiitis (MPA)], 66 with isolated cutaneous vasculitis, and 77 with other vasculitides. Patients with IBD and TAK were younger and had more frequent headaches, constitutional symptoms, or gastrointestinal symptoms compared to those patients in the VCRC who had TAK without IBD.

conclusionsThese findings highlight the risk of vasculitis, especially TAK, in patients with IBD (both CD and UC).

Indexed as

FemaleHumansInflammatory Bowel DiseasesMaleRetrospective StudiesVasculitisCrohn’s diseaseInflammatory bowel diseaseTakayasu arteritisUlcerative colitisVasculitis

Identifiers

PMID26315859
PMCPMC4982464
OpenAlexW1420168619

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.