Evidence map›Paper›PMID 26315817›Full record

ReviewJournal of controlled release : official journal of the Controlled Release Society2015

Nano-enabled delivery of diverse payloads across complex biological barriers.

Kathleen A Ross, Timothy M Brenza, Andrea M Binnebose, Yashdeep Phanse, Anumantha G Kanthasamy, Howard E Gendelman, Aliasger K Salem, Lyric C Bartholomay, Bryan H Bellaire, Balaji Narasimhan

Abstract readReview
In one paragraph

Review in Journal of controlled release : official journal of the Controlled Release Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Nanoparticle delivery systems for substance use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Review
  14. Article
  15. Noncoding RNA therapeutics for substance use disorder.Advances in drug and alcohol research · 2022
    Article
  16. Review
  17. Review
  18. Review
  19. Disentangling Mitochondria in Alzheimer's Disease.International journal of molecular sciences · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kathleen A RossChemical and Biological Engineering, Iowa State University, 2114 Sweeney Hall, Ames 50011, USA.
Timothy M BrenzaChemical and Biological Engineering, Iowa State University, 2114 Sweeney Hall, Ames 50011, USA.
Andrea M BinneboseVeterinary Microbiology and Preventive Medicine, Iowa State University, 2180 Vet Med, Ames 50011, USA.
Yashdeep PhansePathobiological Sciences, University of Wisconsin-Madison, 1656 Linden Dr., Madison 53706, USA.
Anumantha G KanthasamyBiomedical Sciences, Iowa State University, 2008 Vet Med, Ames 50011, USA.
Howard E GendelmanPharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha 68198, USA.
Aliasger K SalemPharmaceutical Sciences and Experimental Therapeutics, University of Iowa, 115 S. Grand Avenue, Iowa City 52242, USA.
Lyric C BartholomayPathobiological Sciences, University of Wisconsin-Madison, 1656 Linden Dr., Madison 53706, USA.
Bryan H BellaireVeterinary Microbiology and Preventive Medicine, Iowa State University, 2180 Vet Med, Ames 50011, USA.
Balaji NarasimhanChemical and Biological Engineering, Iowa State University, 2114 Sweeney Hall, Ames 50011, USA. Electronic address: nbalaji@iastate.edu.

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
The Role of Monocytes in non-Hodgkin LymphomaP50CA097274 · NCI · UNIVERSITY OF IOWA · PI LENTZ, STEVEN R · 2002 to 2021
$45.7M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Therapeutics Core (Page 286)P30MH062261 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BUCH, SHILPA J., FOX, HOWARD S · 2000 to 2021
$37.7M
Pharmacokinetics and Drug-Drug InteractionsP01DA028555 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BOSKA, MICHAEL DOUGLAS · 2010 to 2019
$16.8M
Neuroprotective Immunity and HIV DementiaR01NS034239 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Howard E Gendelman, R Lee Mosley · 1995 to 2026
$12.3M
Nanomedicine and NeuroAIDSR01NS036126 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GENDELMAN, HOWARD E · 1997 to 2017
$5.7M
SMART HANDR01AG043540 · NIA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GENDELMAN, HOWARD E, POLUEKTOVA, LARISA Y · 2013 to 2017
$3.1M
Oxidative Stress Induced Compensatory Protective Mechanisms in PDR01NS074443 · NINDS · IOWA STATE UNIVERSITY · PI KANTHASAMY, ANUMANTHA GOUNDER · 2011 to 2015
$1.6M
NCI NIH HHS P30 CA086862NCI NIH HHS P50 CA097274NCI NIH HHS P50 CA97274/UINIA NIH HHS 5R01 AG043540-02NIA NIH HHS R01 AG043540NIDA NIH HHS P01 DA028555NIEHS NIH HHS P30 ES005605NIMH NIH HHS P30 MH062261NINDS NIH HHS 2R01 NS034239NINDS NIH HHS NS 074443NINDS NIH HHS R01 NS034239NINDS NIH HHS R01 NS036126NINDS NIH HHS R01 NS074443NINDS NIH HHS R01 NS36126
6 · The paper itself

Abstract

Complex biological barriers are major obstacles for preventing and treating disease. Nanocarriers are designed to overcome such obstacles by enhancing drug delivery through physiochemical barriers and improving therapeutic indices. This review critically examines both biological barriers and nanocarrier payloads for a variety of drug delivery applications. A spectrum of nanocarriers is discussed that have been successfully developed for improving tissue penetration for preventing or treating a range of infectious, inflammatory, and degenerative diseases.

Indexed as

AnimalsAnimal ShellsBrainDrug CarriersNanoparticlesNeoplasmsDrug CarriersBiological barriersBlood–brain barrierDrug deliveryNanoparticleTumor microenvironmentVector-borne disease

Identifiers

PMID26315817
PMCPMC4656048

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.