ArticleVeterinary immunology and immunopathology2015
Two novel neutralizing antigenic epitopes of the s1 subunit protein of a QX-like avian infectious bronchitis virus strain Sczy3 as revealed using a phage display peptide library.
Article in Veterinary immunology and immunopathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 22 citations in OpenAlex.
- Emergence of infectious bronchitis virus genotype GI-24 and GI-16 along with predominant circulation of genotype GI-1 in commercial poultry in Bangladesh.Poultry science · 2026Article
- Cross-protection studies using vGA08 and Mass type IBV vaccines against four different antigenic variant viruses currently circulating in poultry in the USA and Canada.Veterinary research · 2026Article
- Molecular surveillance of GI-19 lineage infectious bronchitis virus in China: divergent evolution and efficacy assessment of QXL87 vaccine against heterologous clades.BMC veterinary research · 2025Article
- Two novel conserved linear B-cell epitopes identified in the S2 subunit of the infectious bronchitis virus spike protein.Virus research · 2025Article
- A novel plant-derived recombinant COBRA infectious bronchitis virus spike protein can elicit a strong immune response in chickens.Veterinary research communications · 2025Article
- Identification of B-Cell Epitopes Located on the Surface of the S1 Protein of Infectious Bronchitis Virus M41 Strains.Viruses · 2025Article
- Impact of sodium alginate hydrogel containing bacteriophage peptides that specifically bind to the EtCab protein on the inhibition of Eimeria tenella infection.Veterinary research · 2025Article
- Article
- Bacterial artificial chromosome-based reverse genetics system for cloning and manipulation of the full-length genome of infectious bronchitis virus.Current research in microbial sciences · 2022Article
- Phage Display Technique as a Tool for Diagnosis and Antibody Selection for Coronaviruses.Current microbiology · 2021Review
- Peptide enzyme-linked immunosorbent assay (pELISA) as a possible alternative to the neutralization test for evaluating the immune response to IBV vaccine.BMC veterinary research · 2021Article
- Antigenic and Pathogenic Characteristics of QX-Type Avian Infectious Bronchitis Virus Strains Isolated in Southwestern China.Viruses · 2019Article
- Evolution of infectious bronchitis virus in the field after homologous vaccination introduction.Veterinary research · 2019Article
- Peptides with 16R in S2 protein showed broad reactions with sera against different types of infectious bronchitis viruses.Veterinary microbiology · 2019Article
- Evaluation of the genetic variability found in Brazilian commercial vaccines for infectious bronchitis virus.Virus genes · 2018Article
- Phylogenetic and antigenic analysis of avian infectious bronchitis virus in southwestern China, 2012-2016.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Article
- Prediction and In Silico Identification of Novel B-Cells and T-Cells Epitopes in the S1-Spike Glycoprotein of M41 and CR88 (793/B) Infectious Bronchitis Virus Serotypes for Application in Peptide Vaccines.Advances in bioinformatics · 2016Article
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10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The spike (S) protein of the infectious bronchitis virus (IBV) plays a central role in the pathogenicity, the immune antibody production, serotype and the tissue tropism. In this study, we generate 11 monoclonal antibodies (mAbs) against S1 subunit of IBV Sczy3 strain, and two mAbs 1D5 and 6A12 were positive in indirect ELISA against both His-S1 protein and the purified whole viral antigen. MAb 6A12 and 1D5 could recognized by other 10 IBV strains (IBVs) from five different genotypes, except that 1D5 had a relatively low reaction with two of the 10 tested IBVs. End-point neutralizing assay performed in chicken embro kidney (CEK) cells revealed that the neutralization titer of 6A12 and 1D5 against Sczy3 reached 1:44.7 and 1:40.6, respectively. After screening a phage display peptide library and peptide scanning, we identified two linear B-cell epitopes that were recognized by the mAbs 1D5 and 6A12, which corresponded to the amino acid sequences (87)PPQGMAW(93) and (412)IQTRTEP(418), respectively, in the IBV S1 subunit. Sequences comparison revealed that epitope (412)IQTRTEP(418) was conserved among IBVs, while the epitope (87)PPQGMAW(93) was relatively variable among IBVs. The novel mAbs and the epitopes identified will be useful for developing diagnostic assays for IBV infections.
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