ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2015
The effect of change in body mass index on volumetric measures of mammographic density.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Serum perfluoroalkyl substances (PFASs) concentrations and associations with mammographic density in postmenopausal women.Breast cancer research : BCR · 2026Article
- Longitudinal Mammographic Breast Density Changes and Associated Factors in Older Korean Women.Radiology. Imaging cancer · 2026Article
- Evaluating mammographic density's contribution to improve a breast cancer risk model with questionnaire-based and polygenic factors.NPJ breast cancer · 2025Article
- Article
- Trajectories of breast density change over time and subsequent breast cancer risk: longitudinal study.BMJ (Clinical research ed.) · 2024Article
- Investigating the added value of incorporatingmammographic density to an integrated breastcancer risk model with questionnaire-based riskfactors and polygenic risk score.Research square · 2024Article
- Association between Inflammatory Dietary Pattern and Mammographic Features.The Journal of nutrition · 2024Article
- Temporal changes in mammographic breast density and breast cancer risk among women with benign breast disease.Breast cancer research : BCR · 2024Article
- Short-term changes in ultrasound tomography measures of breast density and treatment-associated endocrine symptoms after tamoxifen therapy.NPJ breast cancer · 2023Article
- Factors Associated with Longitudinal Changes in Mammographic Density in a Multiethnic Breast Screening Cohort of Postmenopausal Women.The breast journal · 2023Article
- Association of mammographic density with blood DNA methylation.Epigenetics · 2022Article
- Fatty liver disease and changes in dense breasts in pre- and postmenopausal women: the Kangbuk Samsung Health Study.Breast cancer research and treatment · 2021Article
- The Relationship between Body Mass Index and Mammographic Density during a Premenopausal Weight Loss Intervention Study.Cancers · 2021Article
- Menopausal Transition, Body Mass Index, and Prevalence of Mammographic Dense Breasts in Middle-Aged Women.Journal of clinical medicine · 2020Article
- Adiposity Change Over the Life Course and Mammographic Breast Density in Postmenopausal Women.Cancer prevention research (Philadelphia, Pa.) · 2020Article
- Rationale, Study Design, and Cohort Characteristics for the Markers for Environmental Exposures (MEE) Study.International journal of environmental research and public health · 2020Article
- Longitudinal Changes in Volumetric Breast Density in Healthy Women across the Menopausal Transition.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Article
- Mammographic density changes in surgical weight loss-an indication for personalized screening.BMC medical imaging · 2018Article
- Docosahexaenoic Acid in Combination with Dietary Energy Restriction for Reducing the Risk of Obesity Related Breast Cancer.International journal of molecular sciences · 2017Review
- Age at Menarche and Late Adolescent Adiposity Associated with Mammographic Density on Processed Digital Mammograms in 24,840 Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Article
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12 authors.
Funding
Abstract
backgroundUnderstanding how changes in body mass index (BMI) relate to changes in mammographic density is necessary to evaluate adjustment for BMI gain/loss in studies of change in density and breast cancer risk. Increase in BMI has been associated with a decrease in percent density, but the effect on change in absolute dense area or volume is unclear.
methodsWe examined the association between change in BMI and change in volumetric breast density among 24,556 women in the San Francisco Mammography Registry from 2007 to 2013. Height and weight were self-reported at the time of mammography. Breast density was assessed using single x-ray absorptiometry measurements. Cross-sectional and longitudinal associations between BMI and dense volume (DV), non-dense volume (NDV), and percent dense volume (PDV) were assessed using multivariable linear regression models, adjusted for demographics, risk factors, and reproductive history.
resultsIn cross-sectional analysis, BMI was positively associated with DV [β, 2.95 cm(3); 95% confidence interval (CI), 2.69-3.21] and inversely associated with PDV (β, -2.03%; 95% CI, -2.09, -1.98). In contrast, increasing BMI was longitudinally associated with a decrease in both DV (β, -1.01 cm(3); 95% CI, -1.59, -0.42) and PDV (β, -1.17%; 95% CI, -1.31, -1.04). These findings were consistent for both pre- and postmenopausal women.
conclusionOur findings support an inverse association between change in BMI and change in PDV. The association between increasing BMI and decreasing DV requires confirmation. IMPACT: Longitudinal studies of PDV and breast cancer risk, or those using PDV as an indicator of breast cancer risk, should evaluate adjustment for change in BMI.
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