Evidence map›Paper›PMID 26315529›Full record

ArticleArthritis care & research2016

Alternative Methods for Defining Osteoarthritis and the Impact on Estimating Prevalence in a US Population-Based Survey.

Miriam G Cisternas, Louise Murphy, Jeffrey J Sacks, Daniel H Solomon, David J Pasta, Charles G Helmick

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis care & research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06608134 (Safety and Feasibility of Umbilical Cord Wharton's Jelly Allograft Injections for), which is not on this map. Cited by 168 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
168citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06608134 early_phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Safety and Feasibility of Umbilical Cord Wharton's Jelly Allograft Injections for

TypeinterventionalSponsorR3 Medical ResearchRan2024 to 2029Enrolled120ConditionsOsteoarthritis, KneeArmsUmbilical Cord Wharton's Jelly Allograft Intra-articular Knee Injection
3 · Its place in the literature

Who cites it

168 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  4. The utility of dried blood spot measurement of bone turnover markers in biological anthropology.American journal of human biology : the official journal of the Human Biology Council · 2022
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108 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Miriam G CisternasMGC Data Services, Carlsbad, California.
Louise MurphyCenters for Disease Control and Prevention, Atlanta, Georgia.
Jeffrey J SacksSue Binder Consulting, Inc., Atlanta, Georgia.
Daniel H SolomonBrigham and Women's Hospital, Boston, Massachusetts.
David J PastaDMA Corporation, Palo Alto, California.
Charles G HelmickCenters for Disease Control and Prevention, Atlanta, Georgia.

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

objectiveProvide a contemporary estimate of osteoarthritis (OA) by comparing the accuracy and prevalence of alternative definitions of OA.

methodsThe Medical Expenditure Panel Survey (MEPS) household component (HC) records respondent-reported medical conditions as open-ended responses; professional coders translate these responses into International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes for the medical conditions files. Using these codes and other data from the MEPS-HC medical conditions files, we constructed 3 case definitions of OA and assessed them against medical provider diagnoses of ICD-9-CM 715 (osteoarthrosis and allied disorders) in a MEPS subsample. The 3 definitions were 1) strict = ICD-9-CM 715; 2) expanded = ICD-9-CM 715, 716 (other and unspecified arthropathies) OR 719 (other and unspecified disorders of joint); and 3) probable = strict OR expanded + respondent-reported prior diagnosis of OA or other arthritis excluding rheumatoid arthritis.

resultsSensitivity and specificity of the 3 definitions, respectively, were 34.6% and 97.5% for strict, 73.8% and 90.5% for expanded, and 62.9% and 93.5% for probable.

conclusionThe strict definition for OA (ICD-9-CM 715) excludes many individuals with OA. The probable definition of OA has the optimal combination of sensitivity and specificity relative to the 2 other MEPS-based definitions and yields a national annual estimate of 30.8 million adults with OA (13.4% of US adult population) for 2008-2011.

Indexed as

International Classification of DiseasesAdolescentAdultAgedFemaleHealth SurveysHumansMaleMiddle AgedOsteoarthritisPrevalenceSensitivity and SpecificityUnited StatesYoung Adult

Identifiers

PMID26315529
PMCPMC4769961

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.