ArticleBMC pediatrics2015
Intraventricular hemorrhage in asphyxiated newborns treated with hypothermia: a look into incidence, timing and risk factors.
Article in BMC pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 37 citations in OpenAlex.
- Therapeutic hypothermia in preterm infants under 36 weeks: Case series on outcomes and brain MRI findings.European journal of pediatrics · 2025Article
- Recent research on the effect of common treatments given in the perinatal period on neurodevelopment in offspring.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Review
- Neuroimaging in the term newborn with neonatal encephalopathy.Seminars in fetal & neonatal medicine · 2021Review
- Is therapeutic hypothermia during neonatal extracorporeal membrane oxygenation associated with intracranial hemorrhage?Perfusion · 2018Article
- Application of Neonatologist Performed Echocardiography in the Assessment and Management of Neonatal Heart Failure unrelated to Congenital Heart Disease.Pediatric research · 2018Review
- Acute symptomatic seizures in term neonates: Etiologies and treatments.Seminars in fetal & neonatal medicine · 2018Review
- Article
- Intraventricular hemorrhage in term neonates with hypoxic-ischemic encephalopathy: a comparison study between neonates treated with and without hypothermia.Quantitative imaging in medicine and surgery · 2016Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundIntraventricular hemorrhage (IVH) is uncommon in term newborns. Asphyxia and hypothermia have been mentioned separately as possible risk factors of IVH, since they might cause fluctuations of cerebral blood flow. The aim of this study was to assess the incidence, the timing, and the risk factors of intraventricular hemorrhage (IVH) in term asphyxiated newborns treated with hypothermia.
methodsWe conducted a prospective cohort study of all term asphyxiated newborns treated with hypothermia from August 2008 to June 2013. The presence or not of IVH was assessed using brain magnetic resonance imaging (MRI) performed after the hypothermia treatment was completed or using head ultrasound during the hypothermia treatment. For these newborns, to determine the timing of IVH, we retrospectively reviewed if they had other brain imaging studies performed during their neonatal hospitalization stay. In addition, we compared their general characteristics with those not developing IVH.
resultsOne hundred and sixty asphyxiated newborns met the criteria for hypothermia. Fifteen of these newborns developed IVH, leading to an estimate of 9% (95% CI: 5.3-15.0%) of IVH in this population of newborns. Fifty-three percent had hemorrhage limited to the choroid plexus or IVH without ventricular dilatation; 47% had IVH with ventricular dilatation or parenchymal hemorrhage. Sixty-seven percent had an initial normal brain imaging; the diagnostic brain imaging that demonstrated the IVH was obtained either during cooling (in 30%), within 24 h of the rewarming (in 30%), or 24 h after the rewarming (in 40%). Recurrent seizures were the presenting symptom of IVH during the rewarming in 20% of the newborns. Coagulopathy was more frequent in the asphyxiated newborns developing IVH (p < 0.001). The asphyxiated newborns developing IVH also presented more frequently with persistent pulmonary hypertension, hypotension, thrombocytopenia and coagulopathy (p = 0.03).
conclusionsThe asphyxiated newborns treated with hypothermia appear to be at an increased risk of IVH, especially those with significant hemodynamic instability. IVH seems to develop during late hypothermia and rewarming. Efforts should be directed towards maintaining hemodynamic stability in these patients, even during the rewarming.
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