ArticlePsychological medicine2015
Reduced contextual effects on visual contrast perception in schizophrenia and bipolar affective disorder.
Article in Psychological medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Atypical Use of Visuospatial Context in Psychotic Psychopathology: A Meta-analysis.Schizophrenia bulletin · 2025Pooled it
- Enhanced visual contrast suppression during peak psilocybin effects: Psychophysical results from a pilot randomized controlled trial.Journal of vision · 2024Trial
- Moderate acute alcohol intoxication increases visual motion repulsion.Scientific reports · 2018Trial
- Retinal Origins of Aberrant Salience in Schizophrenia: The Perceptual Theory.Biological psychiatry global open science · 2026Review
- Dissociating mechanisms of spatial suppression and summation in human visual cortical regions MT/V5: a transcranial Direct Current Stimulation (tDCS) study and clinical implications.International review of psychiatry (Abingdon, England) · 2026Article
- Impaired Contour Object Perception in Psychosis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Low-dose lysergic acid diethylamide alters subjective visual perception but not visual contrast surround suppression.Neuroscience of consciousness · 2026Article
- Article
- Painting psychosis: an empirical investigation of the self-portraits of Edvard Munch.Frontiers in psychiatry · 2025Article
- Altered Use of Context During Visual Perception in Psychotic Psychopathology: A Neurophysiological Investigation of Tuned and Untuned Suppression During Contrast Perception.Schizophrenia bulletin · 2024Article
- Impaired contour object perception in psychosis.medRxiv : the preprint server for health sciences · 2024Article
- Faster bi-stable visual switching in psychosis.Translational psychiatry · 2024Article
- Visual surround suppression at the neural and perceptual levels.Cognitive neurodynamics · 2024Review
- Stronger tilt aftereffects in individuals diagnosed with schizophrenia spectrum disorders but not bipolar disorder.Schizophrenia research · 2024Article
- Generalizing biological surround suppression based on center surround similarity via deep neural network models.PLoS computational biology · 2023Article
- The psychosis human connectome project: Design and rationale for studies of visual neurophysiology.NeuroImage · 2023Article
- Perceptual Center-Surround Contrast Suppression in Adolescence.Investigative ophthalmology & visual science · 2023Article
- Weakened untuned gain control is associated with schizophrenia while atypical orientation-tuned suppression depends on visual acuity.Journal of vision · 2023Article
- Cell-type-specific genes associated with cortical structural abnormalities in pediatric bipolar disorder.Psychoradiology · 2022Article
- A brief psychometric test reveals robust shape completion deficits in schizophrenia that are less severe in bipolar disorder.Schizophrenia research · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundThe salience of a visual stimulus is often reduced by nearby stimuli, an effect known as surround suppression of perceived contrast, which may help in locating the borders of an object. Weaker surround suppression has been observed in schizophrenia but it is unclear whether this abnormality is present in other mental disorders with similar symptomatology, or is evident in people with genetic liability for schizophrenia.
methodBy examining surround suppression among subjects with schizophrenia or bipolar affective disorder, their unaffected biological relatives and healthy controls we sought to determine whether diminished surround suppression was specific to schizophrenia, and if subjects with a genetic risk for either disorder would show similar deficits. Measuring perceived contrast in different surround conditions also allowed us to investigate how this suppression depends on the similarity of target and surrounding stimuli.
resultsSurround suppression was weaker among schizophrenia patients regardless of surround configuration. Subjects with bipolar affective disorder showed an intermediate deficit, with stronger suppression than in schizophrenia but weaker than control subjects. Surround suppression was normal in relatives of both patient groups. Findings support a deficit in broadly tuned (rather than sharply orientation- or direction-selective) suppression mechanisms.
conclusionsWeak broadly tuned suppression during visual perception is evident in schizophrenia and bipolar affective disorder, consistent with impaired gain control related to the clinical expression of these conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.