ArticleOncotarget2015
MiR-625-3p promotes cell migration and invasion via inhibition of SCAI in colorectal carcinoma cells.
Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Regulatory roles of non-coding and exosomal RNAs in colorectal cancer: spotlight on angiogenesis.Clinical and experimental medicine · 2025Review
- Circulating plasma microRNA expression profile: potential minimally invasive biomarker for early detection of coronary artery disease development.Molecular biology reports · 2025Article
- Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives.Cells · 2023Review
- Simple Isothermal and Label-Free Strategy for Colorectal Cancer Potential Biomarker miR-625-5p Detection.Biosensors · 2023Article
- Exosomal mir-625-3p derived from hypoxic lung cancer cells facilitates metastasis by targeting SCAI.Molecular biology reports · 2022Article
- LINC00852 Regulates Cell Proliferation, Invasion, Migration and Apoptosis in Hepatocellular CarcinomaCellular and molecular bioengineering · 2022Article
- Crucial Roles of miR-625 in Human Cancer.Frontiers in medicine · 2022Review
- miR-1290 contributes to oncogenesis and angiogenesis via targeting of THBS1, DKK3 and, SCAI.BioImpacts : BI · 2022Article
- Extracellular Vesicle Enriched miR-625-3p Is Associated with Survival of Malignant Mesothelioma Patients.Journal of personalized medicine · 2021Article
- ZEB1 serves an oncogenic role in the tumourigenesis of HCC by promoting cell proliferation, migration, and inhibiting apoptosis via Wnt/β-catenin signaling pathway.Acta pharmacologica Sinica · 2021Article
- A functional SNP in miR-625-5p binding site of AKT2 3'UTR is associated with noise-induced hearing loss susceptibility in the Chinese population.Environmental science and pollution research international · 2021Article
- Network-based analysis implies critical roles of microRNAs in the long-term cellular responses to gold nanoparticles.Nanoscale · 2020Article
- microRNA-222 promotes colorectal cancer cell migration and invasion by targeting MST3.FEBS open bio · 2019Article
- miR-625-3p promotes migration and invasion and reduces apoptosis of clear cell renal cell carcinoma.American journal of translational research · 2019Article
- Down-regulation of miRNA-148a and miRNA-625-3p in colorectal cancer is associated with tumor budding.BMC cancer · 2017Article
- microRNA-625 inhibits tumorigenicity by suppressing proliferation, migration and invasion in malignant melanoma.Oncotarget · 2017Article
- Unveiling the Impact of the Genomic Architecture on the Evolution of Vertebrate microRNAs.Frontiers in genetics · 2017Review
- The tumor suppressor miR-138-5p targets PD-L1 in colorectal cancer.Oncotarget · 2016Article
- MicroRNA-375 suppresses human colorectal cancer metastasis by targeting Frizzled 8.Oncotarget · 2016Article
- Inhibition of Microrna-766-5p Attenuates the Development of Cervical Cancer Through Regulating SCAI.Technology in cancer research & treatmentArticle
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) play a critical role in controlling tumor invasion and metastasis via regulating the expression of a variety of targets, which act as oncogenes or tumor suppressor genes. Abnormally expressed miR-625-3p has been observed in several types of human cancers. However, the molecular mechanisms of miR-625-3p-mediated tumorigenesis are largely elusive. Therefore, the aim of this study was to evaluate the biological function and molecular insight on miR-625-3p-induced oncogenesis in colorectal carcinoma (CRC). The effects of miR-625-3p in cell migration and invasion were analyzed by wound healing assay and transwell assay, respectively. In addition, the expression of miR-625-3p and its targets was detected in five human CRC cell lines. In the present study, we found that overexpression of miR-625-3p promoted migration and invasion in SW480 cells, whereas downregulation of miR-625-3p inhibited cell motility in SW620 cells. More importantly, we observed potential binding sites for miR-625-3p in the 3'-untranslated region of suppressor of cancer cell invasion (SCAI). Notably, we identified that overexpression of miR-625-3p inhibited the expression of SCAI, while depletion of miR-625-3p increased SCAI level, suggesting that SCAI could be a target of miR-625-3p. Additionally, we revealed that miR-625-3p exerts its oncogenic functions through regulation of SCAI/E-cadherin/MMP-9 pathways. Our findings indicate the pivotal role of miR-625-3p in invasion that warrants further exploration whether targeting miR-625-3p could be a promising approach for the treatment of CRC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.