ArticleMalaria journal2015
Genetic determinants of anti-malarial acquired immunity in a large multi-centre study.
Article in Malaria journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- The interplay between recovery and immunity in infectious and non-communicable diseases.Frontiers in cellular and infection microbiology · 2026Review
- Comparative evaluation of plasma biomarkers of Schistosoma haematobium infection in endemic populations from Burkina Faso.PLoS neglected tropical diseases · 2024Article
- High-dimensional supervised classification in a context of non-independence of observations to identify the determining SNPs in a phenotype.Infectious Disease Modelling · 2023Article
- Cytolytic circumsporozoite-specific memory CD4Nature communications · 2023Article
- High throughput human genotyping for variants associated with malarial disease outcomes using custom targeted amplicon sequencing.Scientific reports · 2023Article
- Risk score prediction model based on single nucleotide polymorphism for predicting malaria: a machine learning approach.BMC bioinformatics · 2022Article
- An In Silico Analysis of Malaria Pre-Erythrocytic-Stage Antigens Interpreting Worldwide Genetic Data to Suggest Vaccine Candidate Variants and Epitopes.Microorganisms · 2022Article
- Leveraging Mann-Whitney U test on large-scale genetic variation data for analysing malaria genetic markers.Malaria journal · 2022Article
- Naturally Acquired Antibodies againstPathogens (Basel, Switzerland) · 2021Review
- Antimalarial Activity ofJournal of experimental pharmacology · 2020Article
- Genetics of Malaria Inflammatory Responses: A Pathogenesis Perspective.Frontiers in immunology · 2019Review
- Host genetic polymorphisms and serological response against malaria in a selected population in Sri Lanka.Malaria journal · 2018Article
- Informing Prevention and Intervention Policy Using Genetic Studies of Resistance.Prevention science : the official journal of the Society for Prevention Research · 2018Article
- Hemoglobin variants shape the distribution of malaria parasites in human populations and their transmission potential.Scientific reports · 2017Article
- Malaria Host Candidate Genes Validated by Association With Current, Recent, and Historical Measures of Transmission Intensity.The Journal of infectious diseases · 2017Article
- Article
- NK Cells: Uncertain Allies against Malaria.Frontiers in immunology · 2017Review
- The application of evolutionary medicine principles for sustainable malaria control: a scoping study.Malaria journal · 2016Article
- Genome-wide association study of antibody responses to Plasmodium falciparum candidate vaccine antigens.Genes and immunity · 2016Article
- Antimalarial Activity of Seed Extracts ofJournal of evidence-based integrative medicineArticle
Corrections and comments
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Authors and funding
58 authors at 20 institutions in 12 countries.
Funding
Abstract
backgroundMany studies report associations between human genetic factors and immunity to malaria but few have been reliably replicated. These studies are usually country-specific, use small sample sizes and are not directly comparable due to differences in methodologies. This study brings together samples and data collected from multiple sites across Africa and Asia to use standardized methods to look for consistent genetic effects on anti-malarial antibody levels.
methodsSera, DNA samples and clinical data were collected from 13,299 individuals from ten sites in Senegal, Mali, Burkina Faso, Sudan, Kenya, Tanzania, and Sri Lanka using standardized methods. DNA was extracted and typed for 202 Single Nucleotide Polymorphisms with known associations to malaria or antibody production, and antibody levels to four clinical grade malarial antigens [AMA1, MSP1, MSP2, and (NANP)4] plus total IgE were measured by ELISA techniques. Regression models were used to investigate the associations of clinical and genetic factors with antibody levels.
resultsMalaria infection increased levels of antibodies to malaria antigens and, as expected, stable predictors of anti-malarial antibody levels included age, seasonality, location, and ethnicity. Correlations between antibodies to blood-stage antigens AMA1, MSP1 and MSP2 were higher between themselves than with antibodies to the (NANP)4 epitope of the pre-erythrocytic circumsporozoite protein, while there was little or no correlation with total IgE levels. Individuals with sickle cell trait had significantly lower antibody levels to all blood-stage antigens, and recessive homozygotes for CD36 (rs321198) had significantly lower anti-malarial antibody levels to MSP2.
conclusionAlthough the most significant finding with a consistent effect across sites was for sickle cell trait, its effect is likely to be via reducing a microscopically positive parasitaemia rather than directly on antibody levels. However, this study does demonstrate a framework for the feasibility of combining data from sites with heterogeneous malaria transmission levels across Africa and Asia with which to explore genetic effects on anti-malarial immunity.
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