ArticleeLife2015
Distinct transcriptional responses elicited by unfolded nuclear or cytoplasmic protein in mammalian cells.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Biological Mechanisms for Allen's Rule: DNA Methylation as Mediator of the Association Between In Utero Exposure to Environmental Heat and Tibial Growth in Childhood.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Transgenic sensors reveal compartment-specific effects of aggregation-prone proteins on subcellular proteostasis during aging.Cell reports methods · 2024Article
- The Aspergillus fumigatus UPR is variably activated across nutrient and host environments and is critical for the establishment of corneal infection.PLoS pathogens · 2023Article
- Ubiquitin receptors play redundant roles in the proteasomal degradation of the p53 repressor MDM2.FEBS letters · 2022Article
- Visualizing the Multistep Process of Protein Aggregation in Live Cells.Accounts of chemical research · 2022Article
- USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L-SMAD pathway.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Reversible Disruption of Specific Transcription Factor-DNA Interactions Using CRISPR/Cas9.Molecular cell · 2019Article
- Widespread PERK-dependent repression of ER targets in response to ER stress.Scientific reports · 2019Article
- Review
- Quality Control of Orphaned Proteins.Molecular cell · 2018Review
- Drug-Inducible Control of Lethality Genes: A Low Background Destabilizing Domain Architecture Applied to the Gal4-UAS System in Drosophila.ACS synthetic biology · 2018Article
- UBE2O is a quality control factor for orphans of multiprotein complexes.Science (New York, N.Y.) · 2017Article
- Induced protein degradation: an emerging drug discovery paradigm.Nature reviews. Drug discovery · 2017Review
- Targeted Protein Degradation by Small Molecules.Annual review of pharmacology and toxicology · 2017Review
- A method to rapidly create protein aggregates in living cells.Nature communications · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Eukaryotic cells possess a variety of signaling pathways that prevent accumulation of unfolded and misfolded proteins. Chief among these is the heat shock response (HSR), which is assumed to respond to unfolded proteins in the cytosol and nucleus alike. In this study, we probe this axiom further using engineered proteins called 'destabilizing domains', whose folding state we control with a small molecule. The sudden appearance of unfolded protein in mammalian cells elicits a robust transcriptional response, which is distinct from the HSR and other known pathways that respond to unfolded proteins. The cellular response to unfolded protein is strikingly different in the nucleus and the cytosol, although unfolded protein in either compartment engages the p53 network. This response provides cross-protection during subsequent proteotoxic stress, suggesting that it is a central component of protein quality control networks, and like the HSR, is likely to influence the initiation and progression of human pathologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.