ArticleHuman brain mapping2015
Effects of APOE promoter polymorphism on the topological organization of brain structural connectome in nondemented elderly.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- A study of brain functional network and alertness changes in temporal lobe epilepsy with and without focal to bilateral tonic-clonic seizures.BMC neurology · 2022Article
- Brain structural network to investigate the mechanism of cognitive impairment in patients with acoustic neuroma.Frontiers in aging neuroscience · 2022Article
- Research on the Mechanism of Cognitive Decline in Patients With Acoustic Neuroma.Frontiers in neuroscience · 2022Article
- Common genetic variation is associated with longitudinal decline and network features in behavioral variant frontotemporal degeneration.Neurobiology of aging · 2021Article
- The human connectome in Alzheimer disease - relationship to biomarkers and genetics.Nature reviews. Neurology · 2021Review
- The Effects of rs405509 onFrontiers in neuroscience · 2021Article
- Brain connectivity during Alzheimer's disease progression and its cognitive impact in a transgenic rat model.Network neuroscience (Cambridge, Mass.) · 2020Article
- Effects of an APOE Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging.Frontiers in aging neuroscience · 2020Article
- Default Mode Network Analysis of APOE Genotype in Cognitively Unimpaired Subjects Based on Persistent Homology.Frontiers in aging neuroscience · 2020Article
- Apolipoprotein E promoter genotypes are not associated with white matter hyperintensity development in high-altitude careers.BMC research notes · 2019Article
- The Contribution of Genetic Factors to Cognitive Impairment and Dementia: Apolipoprotein E Gene, Gene Interactions, and Polygenic Risk.International journal of molecular sciences · 2019Review
- Networks of myelin covariance.Human brain mapping · 2018Article
- Early brain connectivity alterations and cognitive impairment in a rat model of Alzheimer's disease.Alzheimer's research & therapy · 2018Article
- Cognition and connectomes in nondementia idiopathic Parkinson's disease.Network neuroscience (Cambridge, Mass.) · 2018Article
- Integration of white matter network is associated with interindividual differences in psychologically mediated placebo response in migraine patients.Human brain mapping · 2017Article
- Asymmetry of Hemispheric Network Topology Reveals Dissociable Processes between Functional and Structural Brain Connectome in Community-Living Elders.Frontiers in aging neuroscience · 2017Article
- The role of APOE in cerebrovascular dysfunction.Acta neuropathologica · 2016Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
The polymorphism of the Apolipoprotein E (APOE) promoter rs405509 can regulate the transcriptional activity of the APOE gene and is related to Alzheimer's disease (AD). However, its effects on cognitive performance and the underlying brain mechanisms remain unknown. Here, we performed a battery of neuropsychological tests in a large sample (837 subjects) of nondemented elderly Chinese people, and explored the related brain mechanisms via the construction of diffusion MRI-based structural connectome and graph analysis from a subset (84 subjects) of the sample. Cognitively, the rs405509 risk allele (TT) carriers showed decreased attention and execution functions compared with noncarriers (GG/GT). Regarding the topological alterations of the brain connectome, the risk allele group exhibited reduced global and local efficiency of white matter structural networks, mainly in the left anterior and posterior cingulate cortices (PCC). Importantly, the efficiency of the left PCC is correlated with the impaired attention function and mediates the impacts of the rs405509 genotype on attention. These results demonstrated that the rs405509 polymorphism affects attention function in nondemented elderly people, possibly by modulating brain structural connectivity of the PCC. This polymorphism may help us to understand the neural mechanisms of cognitive aging and to serve as a potential marker assessing the risk of AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.