Evidence map›Paper›PMID 26314706›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2015

The level of association between functional performance status measures and patient-reported outcomes in cancer patients: a systematic review.

Thomas M Atkinson, Charissa F Andreotti, Kailey E Roberts, Rebecca M Saracino, Marisol Hernandez, Ethan Basch

Abstract readSystematic Review
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Using Patient-Reported Outcome Measures to Identify Mobility Limitation in Incurable Cancer.Archives of rehabilitation research and clinical translation · 2026
    Article
  8. Article
  9. Observational
  10. Article
  11. Article
  12. Article
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  15. Assessment of rehabilitation practices during hematopoietic stem cell transplantation in the United States: a survey.Rehabilitation oncology (American Physical Therapy Association. Oncology Section) · 2024
    Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Physical activity and fitness in survivors of head and neck cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Thomas M AtkinsonDepartment of Psychiatry & Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave, 7th Floor, New York, NY, 10022, USA. atkinsot@mskcc.org.ORCID http://orcid.org/0000-0002-4965-3913
Charissa F AndreottiDepartment of Psychiatry & Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave, 7th Floor, New York, NY, 10022, USA.
Kailey E RobertsDepartment of Psychiatry & Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave, 7th Floor, New York, NY, 10022, USA.
Rebecca M SaracinoDepartment of Psychiatry & Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave, 7th Floor, New York, NY, 10022, USA.
Marisol HernandezDepartment of Psychiatry & Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave, 7th Floor, New York, NY, 10022, USA.
Ethan BaschUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Psychosocial Palliative & Community Research in CancerT32CA009461 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI JENNIFER L HAY, Jamie S. Ostroff · 1985 to 2026
$10.1M
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA08748-48NCI NIH HHS T32 CA009461NCI NIH HHS T32 CA009461-25
6 · The paper itself

Abstract

purposeThe process of assessing patient symptoms and functionality using patient-reported outcomes (PROs) and functional performance status (FPS) is an essential aspect of patient-centered oncology research and care. However, PRO and FPS measures are often employed separately or inconsistently combined. Thus, the purpose of this study was to conduct a systematic review of the level of association between PRO and FPS measures to determine their differential or combined utility.

methodsA systematic search was conducted using five databases (1966 to February 2014) to identify studies that described an association between PRO and FPS. Studies were excluded if they were non-cancer specific, did not include adults aged 18 or older, or were review articles. Publications were selected for review by consensus among two authors, with a third author arbitrating as needed.

resultsA total of 18 studies met inclusion criteria. FPS was primarily assessed by clinicians using the ECOG Performance Status or Karnofsky Performance Status measures. PROs were captured using a variety of measures, with numerous domains assessed (e.g., pain, fatigue, and general health status). Concordance between PROs and FPS measures was widely variable, falling in the low to moderate range (0.09-0.72).

conclusionsDespite consistency in the method of capture of PROs or FPS, domain capture varied considerably across reviewed studies. Irrespective of the method of capturing PROs or FPS, the quantified level of association between these two areas was moderate at best, providing evidence that FPS and PRO assessments offer unique information to assist clinicians in their decision-making.

Indexed as

Health StatusPatient Outcome AssessmentFemaleHumansMaleNeoplasmsQuality of LifeHealth statusKarnofsky performance statusNeoplasmsPatient outcome assessment

Identifiers

PMID26314706
PMCPMC4832926

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.